Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 115040..115800 Replicon plasmid pML9ba2
Accession NZ_CP092633
Organism Klebsiella variicola subsp. variicola strain ML.9ba2

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag MKK01_RS27075 Protein ID WP_049157791.1
Coordinates 115040..115525 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag MKK01_RS27080 Protein ID WP_211754330.1
Coordinates 115513..115800 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKK01_RS27035 (MKK01_27035) 110981..111229 - 249 WP_020804458.1 DUF905 domain-containing protein -
MKK01_RS27040 (MKK01_27040) 111278..111835 - 558 WP_240289758.1 single-stranded DNA-binding protein -
MKK01_RS27045 (MKK01_27045) 112672..112989 - 318 WP_240289759.1 hypothetical protein -
MKK01_RS27050 (MKK01_27050) 113005..113355 - 351 WP_240289760.1 hypothetical protein -
MKK01_RS27055 (MKK01_27055) 113352..113624 - 273 WP_110244253.1 hypothetical protein -
MKK01_RS27060 (MKK01_27060) 113813..114297 + 485 Protein_117 cytoplasmic protein -
MKK01_RS27065 (MKK01_27065) 114542..114661 - 120 WP_223156217.1 type I toxin-antitoxin system Hok family toxin -
MKK01_RS27070 (MKK01_27070) 114606..114758 - 153 WP_224222653.1 DUF5431 family protein -
MKK01_RS27075 (MKK01_27075) 115040..115525 - 486 WP_049157791.1 GNAT family N-acetyltransferase Toxin
MKK01_RS27080 (MKK01_27080) 115513..115800 - 288 WP_211754330.1 DUF1778 domain-containing protein Antitoxin
MKK01_RS27085 (MKK01_27085) 116205..118400 - 2196 WP_240289761.1 DEAD/DEAH box helicase -
MKK01_RS27090 (MKK01_27090) 118397..119713 - 1317 WP_211754293.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..166327 166327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(25-150)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17795.50 Da        Isoelectric Point: 9.4841

>T236795 WP_049157791.1 NZ_CP092633:c115525-115040 [Klebsiella variicola subsp. variicola]
VGRVTAPEPLSTYHQVAEFVSGETVLDDWLKQKGLKNQALGAARTFVVCKKDTQQIAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQERTLFLKLP
Q

Download         Length: 486 bp

>T236795 NZ_LR738849:c3207852-3207529 [Desulfovibrio sp. 86]
ATGCAGCGCGGTGAAGTCTGGTGGGTAAACTTCGACCCGTCCCAGGGGATGGAGATACAAAAATGCCGCCCTGCCGTGAT
CCTCACGGTCAACGCGCTCAACAAAGCCAGGGGTACGGTCGTGGTGGTGCCGCTTTCCACTTCGGCCAAGCCCCGCCCGC
CCATCGTGGTGCCTCTTGACTCCGCAGGGGCTGGCTCTGTGGCTGTGTGCGACCAGCTTTGCGCGGCAGACAAAAAACGC
TTTGGCAAAAAGCTCTGCGATCTTTCCGCCGCCGACCTGGCCACGTTGACCGAATCCATGAAGATTGTGCTGGGCCTCAT
GTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11030.73 Da        Isoelectric Point: 4.8667

>AT236795 WP_211754330.1 NZ_CP092633:c115800-115513 [Klebsiella variicola subsp. variicola]
MLYKRCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQHAEFIDMLDAPVTDD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT236795 NZ_LR738849:c3208093-3207839 [Desulfovibrio sp. 86]
ATGCAACTGCTGCTTCATATCCCCGACCCCATTGCGGAACGCTTCAAGCAGACCGTGCCTGCCCGCCAGCGAAGCGCCTA
TGTGGCGGATTTGCTCGAAAAGGCTTTGCCCGTGGAAAACGACCCGCTGTACCTCATTGCGCTTGAGGTTGAGCAGGACG
CCGTGCTCAACGCCGAAATGCAGGAGTGGCGCGACGCCCTGATGACTGACGGCATTCGCGGCGAAGAAGTCGGAGGCGCA
CATGCAGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References