Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2717782..2719370 Replicon chromosome
Accession NZ_CP092632
Organism Klebsiella variicola subsp. variicola strain ML.9ba2

Toxin (Protein)


Gene name hipA Uniprot ID A0A0B7G636
Locus tag MKK01_RS13195 Protein ID WP_012968244.1
Coordinates 2717782..2719104 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag MKK01_RS13200 Protein ID WP_008804920.1
Coordinates 2719104..2719370 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKK01_RS13180 (MKK01_13180) 2712847..2715348 + 2502 WP_240289730.1 fimbria/pilus outer membrane usher protein -
MKK01_RS13185 (MKK01_13185) 2715336..2716340 + 1005 WP_117130612.1 fimbrial protein -
MKK01_RS13190 (MKK01_13190) 2716473..2717765 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
MKK01_RS13195 (MKK01_13195) 2717782..2719104 - 1323 WP_012968244.1 type II toxin-antitoxin system HipA family toxin Toxin
MKK01_RS13200 (MKK01_13200) 2719104..2719370 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MKK01_RS13205 (MKK01_13205) 2719636..2719962 - 327 WP_008804921.1 hydroxyisourate hydrolase -
MKK01_RS13210 (MKK01_13210) 2719959..2720459 - 501 WP_023297604.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
MKK01_RS13215 (MKK01_13215) 2720437..2721816 - 1380 WP_012968246.1 nucleobase:cation symporter-2 family protein -
MKK01_RS13220 (MKK01_13220) 2722161..2723315 + 1155 WP_008804924.1 FAD-dependent urate hydroxylase HpxO -
MKK01_RS13225 (MKK01_13225) 2723296..2724219 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48896.29 Da        Isoelectric Point: 7.9109

>T236790 WP_012968244.1 NZ_CP092632:c2719104-2717782 [Klebsiella variicola subsp. variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGELMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T236790 NZ_LR738724:c981202-980357 [Streptococcus suis]
ATGAATAAAGCTAAGCTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGATTAACCTTTAATTCCGTGATGACCTA
TTACTTTCTTGAAGTGATTTTGAAAAAATTAAGTCAGAGTACCTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCAAATGTTATCGGAGTTGAATCACGTAGCACGGTTGATATTGATTTTTTGTTCCATCAAATAACACTCTCAGAAGAT
ACTGTGAAGCAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAATCACAGCTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAGCTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATTACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTTCAAACCATCTATTCACGTAACTTCTTGAACAGTAGAAG
CAAAGATTTTTACGATGTTTATATTCTTTCAAAACTGAAGAAAGAAGACATTGACTTCATTCAGTTGAGAAATGCCTGTC
AGAGAACATTTTCATATCGCGAAACAGAACTCGATTTTGTAAAGATTATTGAACTACTCGAGAGGTTCAAATCTGACCCT
ATTCAGAATAAACAATGGCAAAATTATTCAAAAAAATATAGCTATACAAAAGGGATTTCACTTGCAGATGTTCTTGATGA
GATGATTCGTCTCATAACAGTTCTCATTTCTATAAATTCTGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT236790 WP_008804920.1 NZ_CP092632:c2719370-2719104 [Klebsiella variicola subsp. variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT236790 NZ_LR738724:c981789-981199 [Streptococcus suis]
ATGTCAAAAAAAGAGATTCTACTTGAATTTATAGAAAACCACAATGGCATTATCACCTATAAAGATTGTAAAGCTCTAAA
GATTCCAACAATATATTTGACAAGACTAGAAAAAGAAGGGATTCTATACCGCGTCGAAAAAGGAATTTTCCTAACCCAGA
ATGGAGACTACGACGAATACTACTTCTTTCAGTACCGTTATCCCAAGGCTATTTTCTCTTATATCTCAGCGCTTTACCTG
CAACAATTTACAGATGAAATTCCTCAATATTTTGACGTAACCATTCCTAGAGGCTACCGTTTTAATACTCCTCCAGCAAA
TCTGAACATTCATTCCGTTTCTAAGGAATATAGCGAACTAGGAATTACACTTGTAAAAACCCCTATGGGAAACGAGGTAA
GAGTGTATGATTTAGAACGTATTATCTGTGATTTTGTGATTCATCGAGAAAAAATAGATACTGAGCTTTTTGTCAAAACA
CTTCAACATTACGGAAACTATTCTAAAAAAAATCTTACAAAACTCTATGAATATGCGACAAAAATGAACACCTTGGACAA
GGTCAAACAAACTCTGGAGGTCCTAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7G636

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References