Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 4115747..4116339 Replicon chromosome
Accession NC_012489
Organism Gemmatimonas aurantiaca T-27

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GAU_RS22005 Protein ID WP_083765752.1
Coordinates 4116037..4116339 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1ADF9
Locus tag GAU_RS17840 Protein ID WP_015895305.1
Coordinates 4115747..4116040 (-) Length 98 a.a.

Genomic Context

GAU_RS22660GAU_RS22665GAU_RS17855GAU_RS17815GAU_RS17820GAU_RS17830GAU_RS17835GAU_RS17840GAU_RS22005GAU_RS22520
Location: 4116621..4117052 (432 bp)
Type: Others
Protein ID: WP_015895307.1
Location: 4117063..4117749 (687 bp)
Type: Others
Protein ID: WP_197526011.1
Location: 4118900..4121125 (2226 bp)
Type: Others
Protein ID: WP_041265675.1
Location: 4111519..4112445 (927 bp)
Type: Others
Protein ID: WP_015895300.1
Location: 4112484..4112894 (411 bp)
Type: Others
Protein ID: WP_156799120.1
Location: 4113795..4115027 (1233 bp)
Type: Others
Protein ID: WP_156799121.1
Location: 4115185..4115604 (420 bp)
Type: Others
Protein ID: WP_015895304.1
Location: 4115747..4116040 (294 bp)
Type: Antitoxin
Protein ID: WP_015895305.1
Location: 4116037..4116339 (303 bp)
Type: Toxin
Protein ID: WP_083765752.1
Location: 4118132..4118836 (705 bp)
Type: Others
Protein ID: WP_015895309.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GAU_RS178154111519..4112445-927WP_015895300.1ATP-binding cassette domain-containing protein-
GAU_RS178204112484..4112894-411WP_156799120.1GntR family transcriptional regulator-
GAU_RS178304113795..4115027-1233WP_156799121.1restriction endonuclease-
GAU_RS178354115185..4115604-420WP_015895304.1hypothetical protein-
GAU_RS178404115747..4116040-294WP_015895305.1putative addiction module antidote proteinAntitoxin
GAU_RS220054116037..4116339-303WP_083765752.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GAU_RS226604116621..4117052+432WP_015895307.1transposase-
GAU_RS226654117063..4117749+687WP_197526011.1transposase-
GAU_RS225204118132..4118836-705WP_015895309.1AraC family transcriptional regulator-
GAU_RS178554118900..4121125+2226WP_041265675.1prolyl oligopeptidase family serine peptidase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(7-94)

Antitoxin

Uncharacterized protein HI1420

(5-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11401.10 Da        Isoelectric Point: 9.9161

>T23679 WP_083765752.1 NC_012489:c4116339-4116037 [Gemmatimonas aurantiaca T-27]
ISVFLRTAEFDEWLKALRDPIGKARILARLRAAELGHFGDCASVGDGVFELRVHVGPGYRVYYWRHGAVTYWLLCGGDKS
TQRRDILRAKALRTRVENDP

Download         Length: 303 bp

>T23679 NC_012489:c4116339-4116037 [Gemmatimonas aurantiaca T-27]
ATAAGCGTCTTTCTTCGCACTGCGGAATTCGACGAGTGGCTCAAGGCGCTCCGCGACCCGATCGGCAAGGCGCGCATTCT
TGCTCGGCTTCGCGCTGCGGAGCTCGGCCACTTCGGCGACTGTGCGTCAGTGGGCGACGGCGTCTTTGAGCTTCGCGTTC
ACGTCGGGCCAGGTTATCGGGTGTACTACTGGCGCCACGGTGCCGTCACCTACTGGCTGCTGTGTGGCGGTGACAAGTCG
ACACAGCGCCGGGATATCCTACGGGCCAAGGCCTTGCGTACCCGAGTGGAGAACGATCCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10546.22 Da        Isoelectric Point: 5.6992

>AT23679 WP_015895305.1 NC_012489:c4116040-4115747 [Gemmatimonas aurantiaca T-27]
MKKTVVFDAADYLDSEEVIAEYLNVALASEHPDLFLQAIADVAKARGMAQLAKDTGLGRESLYKALAPGAKPRYDTVLKL
LRALGVEMHMSPAVREA

Download         Length: 294 bp

>AT23679 NC_012489:c4116040-4115747 [Gemmatimonas aurantiaca T-27]
ATGAAGAAGACAGTCGTATTCGATGCAGCGGACTATCTCGACAGCGAGGAAGTCATCGCGGAGTATCTCAACGTCGCGCT
GGCGAGCGAGCATCCGGACCTGTTTCTGCAGGCGATCGCCGACGTGGCGAAGGCGCGCGGCATGGCGCAGTTGGCCAAGG
ACACCGGGCTCGGTCGAGAAAGTTTGTACAAGGCGTTGGCCCCTGGCGCGAAACCACGCTACGACACCGTGCTAAAGTTG
CTTCGCGCGCTGGGGGTTGAGATGCACATGAGCCCGGCCGTTCGCGAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBC1ADF9

References