Detailed information of TA system TA023679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 4115747..4116339
• Replicon: chromosome
• Accession: NC_012489
• Organism: Gemmatimonas aurantiaca T-27

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GAU_RS22005
• Protein ID: WP_083765752.1
• Coordinates: 4116037..4116339 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C1ADF9
• Locus tag: GAU_RS17840
• Protein ID: WP_015895305.1
• Coordinates: 4115747..4116040 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GAU_RS17815	4111519..4112445	-	927	WP_015895300.1	ATP-binding cassette domain-containing protein	-
GAU_RS17820	4112484..4112894	-	411	WP_156799120.1	GntR family transcriptional regulator	-
GAU_RS17830	4113795..4115027	-	1233	WP_156799121.1	restriction endonuclease	-
GAU_RS17835	4115185..4115604	-	420	WP_015895304.1	hypothetical protein	-
GAU_RS17840	4115747..4116040	-	294	WP_015895305.1	putative addiction module antidote protein	Antitoxin
GAU_RS22005	4116037..4116339	-	303	WP_083765752.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GAU_RS22660	4116621..4117052	+	432	WP_015895307.1	transposase	-
GAU_RS22665	4117063..4117749	+	687	WP_197526011.1	transposase	-
GAU_RS22520	4118132..4118836	-	705	WP_015895309.1	AraC family transcriptional regulator	-
GAU_RS17855	4118900..4121125	+	2226	WP_041265675.1	prolyl oligopeptidase family serine peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (7-94)

Antitoxin

• Uncharacterized protein HI1420 (5-90)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11401.10 Da
• Isoelectric Point: 9.9161

>T23679 WP_083765752.1 NC_012489:c4116339-4116037 [Gemmatimonas aurantiaca T-27]
ISVFLRTAEFDEWLKALRDPIGKARILARLRAAELGHFGDCASVGDGVFELRVHVGPGYRVYYWRHGAVTYWLLCGGDKS
TQRRDILRAKALRTRVENDP

Nucleotide

• Length: 303 bp

>T23679 NC_012489:c4116339-4116037 [Gemmatimonas aurantiaca T-27]
ATAAGCGTCTTTCTTCGCACTGCGGAATTCGACGAGTGGCTCAAGGCGCTCCGCGACCCGATCGGCAAGGCGCGCATTCT
TGCTCGGCTTCGCGCTGCGGAGCTCGGCCACTTCGGCGACTGTGCGTCAGTGGGCGACGGCGTCTTTGAGCTTCGCGTTC
ACGTCGGGCCAGGTTATCGGGTGTACTACTGGCGCCACGGTGCCGTCACCTACTGGCTGCTGTGTGGCGGTGACAAGTCG
ACACAGCGCCGGGATATCCTACGGGCCAAGGCCTTGCGTACCCGAGTGGAGAACGATCCATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10546.22 Da
• Isoelectric Point: 5.6992

>AT23679 WP_015895305.1 NC_012489:c4116040-4115747 [Gemmatimonas aurantiaca T-27]
MKKTVVFDAADYLDSEEVIAEYLNVALASEHPDLFLQAIADVAKARGMAQLAKDTGLGRESLYKALAPGAKPRYDTVLKL
LRALGVEMHMSPAVREA

Nucleotide

• Length: 294 bp

>AT23679 NC_012489:c4116040-4115747 [Gemmatimonas aurantiaca T-27]
ATGAAGAAGACAGTCGTATTCGATGCAGCGGACTATCTCGACAGCGAGGAAGTCATCGCGGAGTATCTCAACGTCGCGCT
GGCGAGCGAGCATCCGGACCTGTTTCTGCAGGCGATCGCCGACGTGGCGAAGGCGCGCGGCATGGCGCAGTTGGCCAAGG
ACACCGGGCTCGGTCGAGAAAGTTTGTACAAGGCGTTGGCCCCTGGCGCGAAACCACGCTACGACACCGTGCTAAAGTTG
CTTCGCGCGCTGGGGGTTGAGATGCACATGAGCCCGGCCGTTCGCGAAGCCTAA

Structures

Antitoxin

• AlphaFold DB: C1ADF9