Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 1594614..1595611 | Replicon | chromosome |
| Accession | NZ_CP092632 | ||
| Organism | Klebsiella variicola subsp. variicola strain ML.9ba2 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | MKK01_RS07750 | Protein ID | WP_229531768.1 |
| Coordinates | 1595057..1595611 (-) | Length | 185 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | MKK01_RS07745 | Protein ID | WP_040968744.1 |
| Coordinates | 1594614..1595060 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKK01_RS07730 (MKK01_07730) | 1590909..1591907 | + | 999 | WP_008804028.1 | galactose/glucose ABC transporter substrate-binding protein MglB | - |
| MKK01_RS07735 (MKK01_07735) | 1592026..1593546 | + | 1521 | WP_008804029.1 | galactose/methyl galactoside ABC transporter ATP-binding protein MglA | - |
| MKK01_RS07740 (MKK01_07740) | 1593562..1594572 | + | 1011 | WP_002912871.1 | galactose/methyl galactoside ABC transporter permease MglC | - |
| MKK01_RS07745 (MKK01_07745) | 1594614..1595060 | - | 447 | WP_040968744.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MKK01_RS07750 (MKK01_07750) | 1595057..1595611 | - | 555 | WP_229531768.1 | HipA domain-containing protein | Toxin |
| MKK01_RS07755 (MKK01_07755) | 1595640..1596161 | - | 522 | WP_023340544.1 | hypothetical protein | - |
| MKK01_RS07760 (MKK01_07760) | 1596276..1597007 | - | 732 | WP_008804033.1 | outer membrane permeability protein SanA | - |
| MKK01_RS07765 (MKK01_07765) | 1597300..1598184 | - | 885 | WP_012541034.1 | cytidine deaminase | - |
| MKK01_RS07770 (MKK01_07770) | 1598313..1599008 | - | 696 | WP_008804035.1 | CidB/LrgB family autolysis modulator | - |
| MKK01_RS07775 (MKK01_07775) | 1598998..1599402 | - | 405 | WP_004201620.1 | CidA/LrgA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 185 a.a. Molecular weight: 20710.03 Da Isoelectric Point: 5.7891
>T236780 WP_229531768.1 NZ_CP092632:c1595611-1595057 [Klebsiella variicola subsp. variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL
Download Length: 555 bp
>T236780 NZ_CP092632:c1595611-1595057 [Klebsiella variicola subsp. variicola]
ATGAGATTGGGAATGGAGTCAGTCTATTCTCTGTTACAAAAAGCGCCAGCGACGATACTTGATCATGAAACCACGTTGCG
GATCCTAATCGAAAAGATCACATCCAGTAATATGGTAAGAGTACAGAATTATCGCTTTGATGTTCAAGGATTTATCATCG
ATTGGGTACGTCGAGACTTATTAAACATTATTTTTGGCAATAGTGATAACCATGGACGTAATACTGCATTTATGAAAGCA
GATAATGAAATTATCCTTGCGCCAATCTACGATTTTGCACCAATGAAAGCCGACCCGGAAGGTATACCGCGCACGATGAA
GTGGTCATTAGCCTGCGAATCAGGAGGCGAATATAACTTTGGCGCCATCGCACAAGCTTTGGCTGAATGGATCACCCCTG
ACACATTGCTTAATGCTTTAAGTGAAACCGCATCTCAACTCGTTGATTTACCATCCCGTCTTAAAGTACGCGGCGTTCCT
GTTCAGATTCTGGAAATGCCATCAATTGGTTTTAAATTTATACCTGACAAACTCGCTCGCTGGGGGCTGTTATGA
ATGAGATTGGGAATGGAGTCAGTCTATTCTCTGTTACAAAAAGCGCCAGCGACGATACTTGATCATGAAACCACGTTGCG
GATCCTAATCGAAAAGATCACATCCAGTAATATGGTAAGAGTACAGAATTATCGCTTTGATGTTCAAGGATTTATCATCG
ATTGGGTACGTCGAGACTTATTAAACATTATTTTTGGCAATAGTGATAACCATGGACGTAATACTGCATTTATGAAAGCA
GATAATGAAATTATCCTTGCGCCAATCTACGATTTTGCACCAATGAAAGCCGACCCGGAAGGTATACCGCGCACGATGAA
GTGGTCATTAGCCTGCGAATCAGGAGGCGAATATAACTTTGGCGCCATCGCACAAGCTTTGGCTGAATGGATCACCCCTG
ACACATTGCTTAATGCTTTAAGTGAAACCGCATCTCAACTCGTTGATTTACCATCCCGTCTTAAAGTACGCGGCGTTCCT
GTTCAGATTCTGGAAATGCCATCAATTGGTTTTAAATTTATACCTGACAAACTCGCTCGCTGGGGGCTGTTATGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16422.09 Da Isoelectric Point: 10.4705
>AT236780 WP_040968744.1 NZ_CP092632:c1595060-1594614 [Klebsiella variicola subsp. variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIYDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIYDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK
Download Length: 447 bp
>AT236780 NZ_CP092632:c1595060-1594614 [Klebsiella variicola subsp. variicola]
ATGAAGACCCTGAATAAAAAAGAAACAGAAATCCAAAATACCTTAGCCAGGCTGCGGGCGGATAACCCACCATCCCTACC
CGCCACCGGGGTAACGGCTACGGAAAAAAAAGCTCGTTCAGAGATAAGCAGACAACGCGTCTCGGCTGGTTTAAAAAAAG
TCAAAACGGTCGATCGTCAGGCGGTCATTCACGCCATTATCTATGACATCATGCTAGGCGCCATCAGCCAGGGAGAGGCC
CTGAAAAAACTGAGAGTAGAAGTTCTGGGTTTACGCCAGGATGAATATGCCCGGCTAGTGGATGTCTCTCGTAAGACCTT
ATCTGATGTGGAAAATGATAAAGGCAATTATTCTGCCGAGATCATTAATAAAATCTATAAGCCGTTTGGCCTTGAAACAG
GACTCGTCCCTATTTCTAAAACACTTATTTCTTCTCTATTTAAATAG
ATGAAGACCCTGAATAAAAAAGAAACAGAAATCCAAAATACCTTAGCCAGGCTGCGGGCGGATAACCCACCATCCCTACC
CGCCACCGGGGTAACGGCTACGGAAAAAAAAGCTCGTTCAGAGATAAGCAGACAACGCGTCTCGGCTGGTTTAAAAAAAG
TCAAAACGGTCGATCGTCAGGCGGTCATTCACGCCATTATCTATGACATCATGCTAGGCGCCATCAGCCAGGGAGAGGCC
CTGAAAAAACTGAGAGTAGAAGTTCTGGGTTTACGCCAGGATGAATATGCCCGGCTAGTGGATGTCTCTCGTAAGACCTT
ATCTGATGTGGAAAATGATAAAGGCAATTATTCTGCCGAGATCATTAATAAAATCTATAAGCCGTTTGGCCTTGAAACAG
GACTCGTCCCTATTTCTAAAACACTTATTTCTTCTCTATTTAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|