Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1181177..1181915 Replicon chromosome
Accession NZ_CP092632
Organism Klebsiella variicola subsp. variicola strain ML.9ba2

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag MKK01_RS05810 Protein ID WP_064323817.1
Coordinates 1181177..1181557 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MKK01_RS05815 Protein ID WP_072124521.1
Coordinates 1181589..1181915 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKK01_RS05785 (MKK01_05785) 1177585..1177938 + 354 WP_094285068.1 helix-turn-helix domain-containing protein -
MKK01_RS05790 (MKK01_05790) 1177958..1178530 - 573 WP_049011092.1 flavin reductase -
MKK01_RS05795 (MKK01_05795) 1178742..1179626 + 885 WP_117130972.1 LysR family transcriptional regulator -
MKK01_RS05800 (MKK01_05800) 1179761..1180561 + 801 WP_117130971.1 nucleotidyltransferase domain-containing protein -
MKK01_RS05805 (MKK01_05805) 1180971..1181180 - 210 WP_064323816.1 DUF5983 family protein -
MKK01_RS05810 (MKK01_05810) 1181177..1181557 - 381 WP_064323817.1 TA system toxin CbtA family protein Toxin
MKK01_RS05815 (MKK01_05815) 1181589..1181915 - 327 WP_072124521.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MKK01_RS05820 (MKK01_05820) 1181926..1182393 - 468 WP_072124522.1 DNA repair protein RadC -
MKK01_RS05825 (MKK01_05825) 1182408..1182827 - 420 WP_077263517.1 antirestriction protein -
MKK01_RS05830 (MKK01_05830) 1183361..1186021 + 2661 WP_072124523.1 antiviral RADAR system adenosine triphosphatase RdrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1181177..1199099 17922


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14077.20 Da        Isoelectric Point: 8.5011

>T236779 WP_064323817.1 NZ_CP092632:c1181557-1181177 [Klebsiella variicola subsp. variicola]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLKDTPFGDDSVIQAHINAGISLCDAVNFIVERYELVRTDLSRF
SLPERSSLIGAIDILRARRATGLIVSSGYSTITRITTGRYRKDKTQ

Download         Length: 381 bp

>T236779 NZ_LR738722:c1037542-1037276 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACCTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGCATTGAAGATGACAAATTGATTGTGACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11998.55 Da        Isoelectric Point: 6.0539

>AT236779 WP_072124521.1 NZ_CP092632:c1181915-1181589 [Klebsiella variicola subsp. variicola]
MHSQQWGLTCSKTPCFGARLVQEGNRLHFLADRAGFTGDFSDDEALRLDQAFPLIMKQLEQMLPAGELNPRHQQRVTLNH
IGLTCEADTLGSQGYVYISIYPSSTVTG

Download         Length: 327 bp

>AT236779 NZ_LR738722:c1037777-1037526 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References