Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 788404..789061 Replicon chromosome
Accession NZ_CP092632
Organism Klebsiella variicola subsp. variicola strain ML.9ba2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MKK01_RS03885 Protein ID WP_002916310.1
Coordinates 788651..789061 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MKK01_RS03880 Protein ID WP_002916312.1
Coordinates 788404..788670 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKK01_RS03855 (MKK01_03855) 784846..785574 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
MKK01_RS03860 (MKK01_03860) 785625..785936 + 312 WP_194400676.1 N(4)-acetylcytidine aminohydrolase -
MKK01_RS03865 (MKK01_03865) 786100..786759 + 660 WP_008806429.1 hemolysin III family protein -
MKK01_RS03870 (MKK01_03870) 786790..787128 + 339 WP_130993799.1 hypothetical protein -
MKK01_RS03875 (MKK01_03875) 787175..788158 - 984 WP_087498967.1 tRNA-modifying protein YgfZ -
MKK01_RS03880 (MKK01_03880) 788404..788670 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MKK01_RS03885 (MKK01_03885) 788651..789061 + 411 WP_002916310.1 protein YgfX Toxin
MKK01_RS03890 (MKK01_03890) 789068..789589 - 522 WP_008806427.1 flavodoxin FldB -
MKK01_RS03895 (MKK01_03895) 789690..790586 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
MKK01_RS03900 (MKK01_03900) 790609..791322 + 714 WP_072124461.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MKK01_RS03905 (MKK01_03905) 791328..793061 + 1734 WP_012540594.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T236778 WP_002916310.1 NZ_CP092632:788651-789061 [Klebsiella variicola subsp. variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T236778 NZ_LR738722:799648-799917 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT236778 WP_002916312.1 NZ_CP092632:788404-788670 [Klebsiella variicola subsp. variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT236778 NZ_LR738722:799431-799658 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGTCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References