Detailed information of TA system TA023677

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 3967993..3968583
• Replicon: chromosome
• Accession: NC_012483
• Organism: Acidobacterium capsulatum ATCC 51196

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C1F6V2
• Locus tag: ACP_RS16355
• Protein ID: WP_015898450.1
• Coordinates: 3968305..3968583 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C1F6V1
• Locus tag: ACP_RS16350
• Protein ID: WP_015898449.1
• Coordinates: 3967993..3968301 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACP_RS16340	3963966..3965072	+	1107	WP_148215327.1	DNA-processing protein DprA	-
ACP_RS16345	3965247..3967883	+	2637	WP_015898448.1	type I DNA topoisomerase	-
ACP_RS16350	3967993..3968301	+	309	WP_015898449.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ACP_RS16355	3968305..3968583	+	279	WP_015898450.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
ACP_RS16360	3968638..3969078	+	441	WP_015898451.1	hypothetical protein	-
ACP_RS16365	3969180..3969464	+	285	WP_015898452.1	DUF427 domain-containing protein	-
ACP_RS16370	3969623..3970531	+	909	WP_015898453.1	class A beta-lactamase	-
ACP_RS16375	3970692..3971705	+	1014	WP_041839693.1	sensor domain-containing diguanylate cyclase	-
ACP_RS17885	3972238..3972636	+	399	WP_041840436.1	DUF2251 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-61)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10508.15 Da
• Isoelectric Point: 10.6975

>T23677 WP_015898450.1 NC_012483:3968305-3968583 [Acidobacterium capsulatum ATCC 51196]
MKIHWTSAALTDRMAIFTYIAQDRPQTATAVDARIRSLVEQLARFPNRGRSGRMTESRELVIPQTPYLAIYRIDGHTISI
LRILHGSQCWPA

Nucleotide

• Length: 279 bp

>T23677 NC_012483:3968305-3968583 [Acidobacterium capsulatum ATCC 51196]
ATGAAGATTCACTGGACCTCAGCCGCGCTTACGGATCGCATGGCCATTTTTACTTACATTGCCCAGGACCGTCCGCAGAC
AGCGACTGCAGTGGATGCGCGCATTCGTTCGCTTGTTGAGCAACTGGCTCGCTTTCCGAATAGGGGAAGATCAGGGCGCA
TGACAGAGAGCCGCGAACTGGTCATCCCCCAGACCCCTTACCTGGCCATCTACCGCATCGACGGGCACACCATCTCTATC
CTCCGCATCCTGCATGGCTCACAGTGCTGGCCCGCCTAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11491.24 Da
• Isoelectric Point: 7.2060

>AT23677 WP_015898449.1 NC_012483:3967993-3968301 [Acidobacterium capsulatum ATCC 51196]
MAANALVQTRIDPEVKDRAAAVLERMGLTVSDAVRILLTRTANEGALPFAVTPTPEEYDAWFRKKVQEALDDPRPMIPHE
EVERRMAVHRAAILNLSRDTKK

Nucleotide

• Length: 309 bp

>AT23677 NC_012483:3967993-3968301 [Acidobacterium capsulatum ATCC 51196]
ATGGCCGCCAATGCTCTCGTCCAGACCCGCATCGATCCCGAGGTGAAAGACCGCGCCGCTGCCGTGCTGGAGCGCATGGG
GCTCACCGTCTCCGATGCGGTTCGCATCCTGCTCACCCGCACCGCCAATGAGGGAGCCTTGCCCTTTGCAGTCACTCCCA
CGCCAGAAGAGTACGACGCGTGGTTCCGCAAAAAAGTGCAGGAAGCGCTCGATGATCCACGCCCGATGATCCCGCATGAA
GAAGTAGAACGTCGTATGGCTGTTCATCGCGCGGCAATCTTGAATCTGTCCAGGGACACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: C1F6V2

Antitoxin

• AlphaFold DB: C1F6V1