236765

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 522619..523255 Replicon chromosome
Accession NZ_CP092631
Organism Bacillus subtilis strain YB-15

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag MKS87_RS02705 Protein ID WP_003156187.1
Coordinates 522905..523255 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G4NU32
Locus tag MKS87_RS02700 Protein ID WP_003225183.1
Coordinates 522619..522900 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKS87_RS02680 (518979) 518979..519578 - 600 WP_029317326.1 rhomboid family intramembrane serine protease -
MKS87_RS02685 (519673) 519673..520038 + 366 WP_015252768.1 holo-ACP synthase -
MKS87_RS02690 (520204) 520204..521220 + 1017 WP_173614400.1 outer membrane lipoprotein carrier protein LolA -
MKS87_RS02695 (521334) 521334..522503 + 1170 WP_173613923.1 alanine racemase -
MKS87_RS02700 (522619) 522619..522900 + 282 WP_003225183.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
MKS87_RS02705 (522905) 522905..523255 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
MKS87_RS02710 (523370) 523370..524194 + 825 WP_009966610.1 RsbT co-antagonist protein RsbRA -
MKS87_RS02715 (524199) 524199..524564 + 366 WP_003225190.1 RsbT antagonist protein RsbS -
MKS87_RS02720 (524568) 524568..524969 + 402 WP_003246640.1 serine/threonine-protein kinase RsbT -
MKS87_RS02725 (524981) 524981..525988 + 1008 WP_003234295.1 phosphoserine phosphatase RsbU -
MKS87_RS02730 (526050) 526050..526379 + 330 WP_003234298.1 anti-sigma factor antagonist RsbV -
MKS87_RS02735 (526376) 526376..526858 + 483 WP_003234299.1 anti-sigma B factor RsbW -
MKS87_RS02740 (526824) 526824..527612 + 789 WP_003246715.1 RNA polymerase sigma factor SigB -
MKS87_RS02745 (527612) 527612..528211 + 600 WP_003246608.1 phosphoserine phosphatase RsbX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T236765 WP_003156187.1 NZ_CP092631:522905-523255 [Bacillus subtilis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T236765 NZ_LR738720:772980-773768 [Streptococcus suis]
ATGAGATTGGAAGAATTTAGTGAGGTAGAGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCTTTAACTCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCCATTTTACTTGGAGGTCAAAGCGGGGCAGGTAAGACGACTATTCATCGAATTAAACAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCACTGCAAGAA
AAGTATGGCAAGGACAGTGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGATGAACTTAGCAC
ACAAGGTTATCATTTGTTAATTGAAGGGACTTTACGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAACTTCTA
AAGGTTACCAAGTTTCTTTAGCTATTATTGGTACCAAACCAGAACTGTCCTATCTCAGCACCTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCGACGCAGGCCAGAGCAACACCCAAAGACCACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGAGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGATAGGGCTTGTATCTATGATTCTG
AAACGGATGAAGGTTCCGCAGCAGAAGTTCTACAAGACTGCCTCTTTGGAAAATGTAGTAAGGTTGAGGAAGAGATGATG
AAGTTAGGTCGGGAACGGTTAGTTAAACTGAATAATAAGAATTTGCTGGAGAGTAACTATGGAATTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10546.92 Da        Isoelectric Point: 6.4708

>AT236765 WP_003225183.1 NZ_CP092631:522619-522900 [Bacillus subtilis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT236765 NZ_LR738720:772504-772980 [Streptococcus suis]
ATGATTGGAGACAATATTAAATCACTACGCCGAACACACGATTTAACACAACCAGAATTTGCGAAAATGGTCGGGATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGAACCAGCACCGTTTCAACAGAACTCATTGACCGCATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAAAATAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCTCAACTCTATCGATATCAGGATAGTCAAGGTATTGCTTTTGATGATGA
AACAAATCCTTGGATTTTGATGAGTGATGATTTGGCTGAATTGATCAATACGAAAATATACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8

Antitoxin

Source ID Structure
AlphaFold DB G4NU32

References