236764

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4036585..4038126 Replicon chromosome
Accession NZ_CP092630
Organism Shewanella xiamenensis strain CQ-Y1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MKD32_RS17735 Protein ID WP_240292528.1
Coordinates 4036585..4037886 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MKD32_RS17740 Protein ID WP_047539109.1
Coordinates 4037890..4038126 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKD32_RS17715 (MKD32_17715) 4032774..4033148 - 375 WP_240292526.1 hypothetical protein -
MKD32_RS17720 (MKD32_17720) 4033394..4034284 + 891 WP_159372973.1 site-specific integrase -
MKD32_RS17725 (MKD32_17725) 4034281..4035366 + 1086 WP_069453528.1 IS91 family transposase -
MKD32_RS17730 (MKD32_17730) 4035620..4035847 - 228 WP_240292527.1 hypothetical protein -
MKD32_RS17735 (MKD32_17735) 4036585..4037886 - 1302 WP_240292528.1 type II toxin-antitoxin system toxin serine/threonine-protein kinase HipA Toxin
MKD32_RS17740 (MKD32_17740) 4037890..4038126 - 237 WP_047539109.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MKD32_RS17745 (MKD32_17745) 4038542..4040179 - 1638 WP_037430013.1 chaperonin GroEL -
MKD32_RS17750 (MKD32_17750) 4040238..4040528 - 291 WP_011071021.1 co-chaperone GroES -
MKD32_RS17755 (MKD32_17755) 4040756..4042114 + 1359 WP_140907373.1 MATE family efflux transporter -
MKD32_RS17760 (MKD32_17760) 4042111..4043100 - 990 WP_109277898.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48730.02 Da        Isoelectric Point: 5.3231

>T236764 WP_240292528.1 NZ_CP092630:c4037886-4036585 [Shewanella xiamenensis]
MSTAKTLTLEMHLGDLMIGELSFDATTDTFAVYYTKDWQQSGFPLSPTIPLDGTGTSNQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAIAFVPKGALLTETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GKEFAFAEGTLSSTHIVKFEKYHHLVINEFITMRLAKVIGMNVANVDIVHFGSYKALCVERFDRRYIPSEQRVLRRHIVD
SCQALGFSVSKKYERNFGTGRDVKDIREGVSFNRLFSLAAKCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFEPNSIYAYQLAAFMDGLGLPRNLLVSNLTRIARRIPQAIAEVILMLPPLD
EDEASFVAHYKAQLLARCERYLSFADEVRDVEV

Download         Length: 1302 bp

>T236764 NZ_LR738720:767264-767533 [Streptococcus suis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGATCAGGTAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAGACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCTAGAAGCACGTTCGCCAAT
GTCAACAAGAGAAATAACTTTAACAGTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8500.83 Da        Isoelectric Point: 7.9727

>AT236764 WP_047539109.1 NZ_CP092630:c4038126-4037890 [Shewanella xiamenensis]
MASPLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIDIVSAQTSNTETNGWY

Download         Length: 237 bp

>AT236764 NZ_LR738720:766990-767262 [Streptococcus suis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References