Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 6229153..6230848 | Replicon | chromosome |
| Accession | NZ_CP092629 | ||
| Organism | Pseudomonas aeruginosa strain HU20 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9HYA0 |
| Locus tag | MKF35_RS28890 | Protein ID | WP_003112901.1 |
| Coordinates | 6229979..6230848 (-) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q9HYA1 |
| Locus tag | MKF35_RS28885 | Protein ID | WP_003112902.1 |
| Coordinates | 6229153..6229986 (-) | Length | 278 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKF35_RS28865 | 6224384..6225868 | - | 1485 | WP_003453562.1 | aldehyde dehydrogenase | - |
| MKF35_RS28870 | 6225880..6226683 | - | 804 | WP_003130116.1 | aspartate dehydrogenase | - |
| MKF35_RS28875 | 6226694..6228376 | - | 1683 | WP_003130114.1 | thiamine pyrophosphate-binding protein | - |
| MKF35_RS28880 | 6228369..6229166 | - | 798 | WP_003112903.1 | SDR family oxidoreductase | - |
| MKF35_RS28885 | 6229153..6229986 | - | 834 | WP_003112902.1 | IclR family transcriptional regulator | Antitoxin |
| MKF35_RS28890 | 6229979..6230848 | - | 870 | WP_003112901.1 | alpha/beta hydrolase | Toxin |
| MKF35_RS28895 | 6230857..6231387 | - | 531 | WP_003112900.1 | cupin domain-containing protein | - |
| MKF35_RS28900 | 6231401..6232162 | - | 762 | WP_003112899.1 | SDR family oxidoreductase | - |
| MKF35_RS28905 | 6232168..6232944 | - | 777 | WP_003112898.1 | ABC transporter permease | - |
| MKF35_RS28910 | 6232941..6233948 | - | 1008 | WP_003112897.1 | ABC transporter substrate-binding protein | - |
| MKF35_RS28915 | 6233989..6234840 | - | 852 | WP_003130104.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30403.60 Da Isoelectric Point: 6.5894
>T236760 WP_003112901.1 NZ_CP092629:c6230848-6229979 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
Download Length: 870 bp
>T236760 NZ_LR735440:1862702-1863163 [Staphylococcus epidermidis]
ATGGGGTTATATGAAAAAATGTTAATAAAACATGATTATATAGAAGTCAGAGAAACAAATGTTATGCCTAATGACCTACA
CGGTCTATGGTTAGGTGATTTAATTTTAATTAAGCGAAACCTTTCCGAAACACGTAAAGCTGAGGTATTATACGAAGAAC
TAACACACCATAAACTTACATATGGAAACATCTTAGACCAATCTAAATTCAACAACCGTAAATTTGAAAACTACGCTAGG
CGTTACGGGTATGAAAATGCCCTACCTTTGCGCATTATTGTGGAGGCGCATAACTATGGTATTAGTAACTTATATGAACT
AGCTGAATATGTTCAATTAAGCGAAGAATATATAGTAGAAATATTGAAACATTACAAAAATAAATATGGTATTGGTACTC
ACTACGGAGAATACCTAATTACATTTGATCCGTTGAGGGTTTTTAAATATAAAGAAATATAA
ATGGGGTTATATGAAAAAATGTTAATAAAACATGATTATATAGAAGTCAGAGAAACAAATGTTATGCCTAATGACCTACA
CGGTCTATGGTTAGGTGATTTAATTTTAATTAAGCGAAACCTTTCCGAAACACGTAAAGCTGAGGTATTATACGAAGAAC
TAACACACCATAAACTTACATATGGAAACATCTTAGACCAATCTAAATTCAACAACCGTAAATTTGAAAACTACGCTAGG
CGTTACGGGTATGAAAATGCCCTACCTTTGCGCATTATTGTGGAGGCGCATAACTATGGTATTAGTAACTTATATGAACT
AGCTGAATATGTTCAATTAAGCGAAGAATATATAGTAGAAATATTGAAACATTACAAAAATAAATATGGTATTGGTACTC
ACTACGGAGAATACCTAATTACATTTGATCCGTTGAGGGTTTTTAAATATAAAGAAATATAA
Antitoxin
Download Length: 278 a.a. Molecular weight: 30877.26 Da Isoelectric Point: 5.7725
>AT236760 WP_003112902.1 NZ_CP092629:c6229986-6229153 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV
Download Length: 834 bp
>AT236760 NZ_LR735440:1862361-1862690 [Staphylococcus epidermidis]
ATGAGAAATAATGATGAAATAATCACAATAATTAAATCAGCTATGAAAGAACAAGATATGTCACTTAGTGAATTAGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTATCACGTTATTTAAACTTAACTAGAGAATTTCCGTTAAATCGTACAGAAGATT
TTGCAAAAGCACTTAGTATCAGTACAGAATACTTACTTGGTTTTGACAAAAGTGAACAACAAGATGAACAACCAAAACAT
CGTGCAGCACATCTTGAAGGTGAATTAACAGATGAAGAATGGCAACGTGTGCTAGATTATGCAGATTATATAAGAAGCAA
ACGCAAATAA
ATGAGAAATAATGATGAAATAATCACAATAATTAAATCAGCTATGAAAGAACAAGATATGTCACTTAGTGAATTAGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTATCACGTTATTTAAACTTAACTAGAGAATTTCCGTTAAATCGTACAGAAGATT
TTGCAAAAGCACTTAGTATCAGTACAGAATACTTACTTGGTTTTGACAAAAGTGAACAACAAGATGAACAACCAAAACAT
CGTGCAGCACATCTTGAAGGTGAATTAACAGATGAAGAATGGCAACGTGTGCTAGATTATGCAGATTATATAAGAAGCAA
ACGCAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|