Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3794572..3795596 | Replicon | chromosome |
| Accession | NC_012483 | ||
| Organism | Acidobacterium capsulatum ATCC 51196 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | ACP_RS15625 | Protein ID | WP_015898304.1 |
| Coordinates | 3794572..3795144 (-) | Length | 191 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | C1F5T6 |
| Locus tag | ACP_RS15630 | Protein ID | WP_015898305.1 |
| Coordinates | 3795147..3795596 (-) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACP_RS15610 | 3790419..3792386 | - | 1968 | WP_015898302.1 | DUF3732 domain-containing protein | - |
| ACP_RS15615 | 3792386..3792892 | - | 507 | WP_052294845.1 | hypothetical protein | - |
| ACP_RS15620 | 3792876..3794075 | - | 1200 | WP_148215184.1 | hypothetical protein | - |
| ACP_RS18180 | 3794385..3794553 | + | 169 | Protein_3085 | IS3 family transposase | - |
| ACP_RS15625 | 3794572..3795144 | - | 573 | WP_015898304.1 | PIN domain-containing protein | Toxin |
| ACP_RS15630 | 3795147..3795596 | - | 450 | WP_015898305.1 | excisionase family DNA-binding protein | Antitoxin |
| ACP_RS15635 | 3796233..3797123 | - | 891 | WP_015898306.1 | dihydrodipicolinate synthase family protein | - |
| ACP_RS15640 | 3797136..3798428 | - | 1293 | WP_015898307.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| ACP_RS15645 | 3798421..3798666 | - | 246 | WP_041839667.1 | (2Fe-2S)-binding protein | - |
| ACP_RS15650 | 3798659..3799792 | - | 1134 | WP_015898308.1 | FAD-binding oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 3658978..3795888 | 136910 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 191 a.a. Molecular weight: 21706.84 Da Isoelectric Point: 4.8019
>T23676 WP_015898304.1 NC_012483:c3795144-3794572 [Acidobacterium capsulatum ATCC 51196]
VAAFIVFFDANVLYPAELRSFLMYLALTGVFRAQWSADVHEEWIRNLLKNRPDLTREKLERTRQLMDQAAPDALVTAYEH
LIPGLFLPDENDRHVLAAAIRCRASVIVTCNLEDFPREALREFNIEAQHPDEFIFNLFDLSPGLVIEAAENHRSSLKNPP
KSVDEYLAMLEMQGLTQTTSALREYMGGLK
VAAFIVFFDANVLYPAELRSFLMYLALTGVFRAQWSADVHEEWIRNLLKNRPDLTREKLERTRQLMDQAAPDALVTAYEH
LIPGLFLPDENDRHVLAAAIRCRASVIVTCNLEDFPREALREFNIEAQHPDEFIFNLFDLSPGLVIEAAENHRSSLKNPP
KSVDEYLAMLEMQGLTQTTSALREYMGGLK
Download Length: 573 bp
>T23676 NC_012483:c3795144-3794572 [Acidobacterium capsulatum ATCC 51196]
GTGGCGGCATTCATTGTCTTCTTCGACGCGAATGTACTCTATCCCGCTGAGTTGCGAAGCTTCCTCATGTATCTCGCATT
GACGGGAGTGTTTCGTGCCCAGTGGTCCGCAGATGTACATGAAGAATGGATCAGGAATCTCTTGAAGAACCGGCCCGACC
TCACTCGCGAGAAGTTGGAACGCACGAGGCAGCTCATGGATCAAGCCGCTCCAGATGCGCTCGTAACAGCATATGAACAC
CTCATTCCGGGCCTTTTCTTGCCAGATGAAAATGACCGCCATGTCCTGGCGGCGGCGATCCGCTGCAGAGCCAGTGTCAT
CGTCACATGCAATTTGGAGGACTTTCCCCGCGAGGCGCTCCGGGAATTCAATATAGAGGCACAGCATCCAGACGAGTTCA
TTTTCAATCTGTTTGATCTCTCCCCAGGCTTGGTCATTGAAGCCGCTGAAAATCATAGAAGCAGTCTCAAGAATCCGCCG
AAATCTGTGGATGAATACCTCGCGATGCTGGAAATGCAAGGGTTAACACAGACGACCTCTGCGCTCCGTGAATACATGGG
TGGCCTGAAGTAG
GTGGCGGCATTCATTGTCTTCTTCGACGCGAATGTACTCTATCCCGCTGAGTTGCGAAGCTTCCTCATGTATCTCGCATT
GACGGGAGTGTTTCGTGCCCAGTGGTCCGCAGATGTACATGAAGAATGGATCAGGAATCTCTTGAAGAACCGGCCCGACC
TCACTCGCGAGAAGTTGGAACGCACGAGGCAGCTCATGGATCAAGCCGCTCCAGATGCGCTCGTAACAGCATATGAACAC
CTCATTCCGGGCCTTTTCTTGCCAGATGAAAATGACCGCCATGTCCTGGCGGCGGCGATCCGCTGCAGAGCCAGTGTCAT
CGTCACATGCAATTTGGAGGACTTTCCCCGCGAGGCGCTCCGGGAATTCAATATAGAGGCACAGCATCCAGACGAGTTCA
TTTTCAATCTGTTTGATCTCTCCCCAGGCTTGGTCATTGAAGCCGCTGAAAATCATAGAAGCAGTCTCAAGAATCCGCCG
AAATCTGTGGATGAATACCTCGCGATGCTGGAAATGCAAGGGTTAACACAGACGACCTCTGCGCTCCGTGAATACATGGG
TGGCCTGAAGTAG
Antitoxin
Download Length: 150 a.a. Molecular weight: 16631.39 Da Isoelectric Point: 8.5245
>AT23676 WP_015898305.1 NC_012483:c3795596-3795147 [Acidobacterium capsulatum ATCC 51196]
MSQTLLIPTLPTETDATLARETSRLLAPRMRSKAPLRVRVVGAAKEETLELPAPAVQMLIRILEEMARGNAVTLIPVHAE
LTTQEAADMLNISRPSLIQLLDEGKMEYRKVGTHRRVRFDALMAYKRQADADRRAALAELVAYDQEIGI
MSQTLLIPTLPTETDATLARETSRLLAPRMRSKAPLRVRVVGAAKEETLELPAPAVQMLIRILEEMARGNAVTLIPVHAE
LTTQEAADMLNISRPSLIQLLDEGKMEYRKVGTHRRVRFDALMAYKRQADADRRAALAELVAYDQEIGI
Download Length: 450 bp
>AT23676 NC_012483:c3795596-3795147 [Acidobacterium capsulatum ATCC 51196]
ATGTCCCAGACACTTCTCATACCAACCCTTCCCACAGAGACCGATGCCACGCTTGCACGGGAGACCAGCCGTCTGCTCGC
CCCTCGTATGCGCTCAAAGGCACCGCTCCGCGTGCGCGTTGTCGGCGCAGCCAAAGAAGAAACATTGGAACTTCCGGCTC
CCGCCGTCCAAATGCTCATTCGCATTCTGGAGGAGATGGCGCGCGGAAATGCCGTAACCTTGATTCCAGTCCACGCTGAG
TTAACCACACAGGAAGCGGCGGACATGCTGAACATCTCGCGCCCGTCCCTGATTCAGCTATTGGACGAGGGGAAGATGGA
GTATCGGAAGGTTGGCACGCATCGTCGCGTTCGCTTCGATGCCCTGATGGCCTACAAACGCCAAGCGGATGCAGATCGCC
GGGCGGCTCTTGCCGAACTGGTGGCCTATGACCAGGAGATCGGGATCTGA
ATGTCCCAGACACTTCTCATACCAACCCTTCCCACAGAGACCGATGCCACGCTTGCACGGGAGACCAGCCGTCTGCTCGC
CCCTCGTATGCGCTCAAAGGCACCGCTCCGCGTGCGCGTTGTCGGCGCAGCCAAAGAAGAAACATTGGAACTTCCGGCTC
CCGCCGTCCAAATGCTCATTCGCATTCTGGAGGAGATGGCGCGCGGAAATGCCGTAACCTTGATTCCAGTCCACGCTGAG
TTAACCACACAGGAAGCGGCGGACATGCTGAACATCTCGCGCCCGTCCCTGATTCAGCTATTGGACGAGGGGAAGATGGA
GTATCGGAAGGTTGGCACGCATCGTCGCGTTCGCTTCGATGCCCTGATGGCCTACAAACGCCAAGCGGATGCAGATCGCC
GGGCGGCTCTTGCCGAACTGGTGGCCTATGACCAGGAGATCGGGATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|