Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4278599..4279820 Replicon chromosome
Accession NZ_CP092629
Organism Pseudomonas aeruginosa strain HU20

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MKF35_RS19920 Protein ID WP_003114949.1
Coordinates 4278599..4279177 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MKF35_RS19925 Protein ID WP_003088112.1
Coordinates 4279266..4279820 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKF35_RS19905 4273876..4275153 + 1278 WP_003102743.1 TolC family protein -
MKF35_RS19910 4275143..4277314 + 2172 WP_009876279.1 type I secretion system permease/ATPase -
MKF35_RS19915 4277304..4278491 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
MKF35_RS19920 4278599..4279177 - 579 WP_003114949.1 HD domain-containing protein Toxin
MKF35_RS19925 4279266..4279820 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
MKF35_RS19930 4279978..4282173 - 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
MKF35_RS19935 4282178..4282639 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
MKF35_RS19940 4282970..4283293 + 324 WP_003102734.1 multidrug efflux SMR transporter -
MKF35_RS19945 4283306..4283704 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
MKF35_RS19950 4283701..4284252 - 552 WP_047105619.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T236758 WP_003114949.1 NZ_CP092629:c4279177-4278599 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T236758 NZ_LR735440:900224-900586 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT236758 WP_003088112.1 NZ_CP092629:c4279820-4279266 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT236758 NZ_LR735440:900057-900227 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References