Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1344556..1345061 Replicon chromosome
Accession NZ_CP092629
Organism Pseudomonas aeruginosa strain HU20

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag MKF35_RS06290 Protein ID WP_003121619.1
Coordinates 1344780..1345061 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag MKF35_RS06285 Protein ID WP_003112628.1
Coordinates 1344556..1344783 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKF35_RS06260 1339574..1341067 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
MKF35_RS06265 1341236..1342663 + 1428 WP_003083784.1 GABA permease -
MKF35_RS06270 1342745..1343086 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
MKF35_RS06275 1343159..1343659 - 501 WP_003112629.1 LEA type 2 family protein -
MKF35_RS06280 1343760..1344380 + 621 WP_003101226.1 hypothetical protein -
MKF35_RS06285 1344556..1344783 + 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
MKF35_RS06290 1344780..1345061 + 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
MKF35_RS06295 1345361..1346269 + 909 WP_047106216.1 LysR family transcriptional regulator -
MKF35_RS06300 1346301..1346711 - 411 WP_003101225.1 aegerolysin family protein -
MKF35_RS06305 1346891..1347625 - 735 WP_003117208.1 GntR family transcriptional regulator -
MKF35_RS06310 1347726..1348412 - 687 WP_047106214.1 FadR/GntR family transcriptional regulator -
MKF35_RS06315 1348461..1349810 - 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T236755 WP_003121619.1 NZ_CP092629:1344780-1345061 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T236755 NZ_LR735437:2291333-2291803 [Staphylococcus epidermidis]
GTGGGTAAATACGAAGATTTGATGATTAAATACGACCATTTACCTATTACAGAAACTAAATATATGCCGGACTTCATGTC
CGGTCTGTATTTAGACGGAGAAATATTTATCAATGATAATAGAAGTGTTAGGCAGAAGTTAGAAACACTAGCAGAAGAAA
TAGCTCATCATAAGTTAACACACGGGAATATAACAAACAGTGATGAGTACAACAATCGTAAGTTTGAGAATTATGCTAGA
CGTTATGCTAAAGAAACAGTGATTTCTTTAGACGGTTTGATAGAAGCACATAGACGAGGAATCAACAGTCTTTATGAATT
ATCAGAGTTTTTCGAAGTTACGGAAGAATATGTTTTAGATTGTTTGAATCATTATAAAAGTAAATATGGCTTGTCTGTGA
TTCACGATGATTACACGATATATTTTGAACCATTAAGCGTTATCAAAAATAAAAGGAGAGATGCAGAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT236755 WP_003112628.1 NZ_CP092629:1344556-1344783 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT236755 NZ_LR735437:2291009-2291320 [Staphylococcus epidermidis]
ATGAGTATTGGTAACAGAATAAAAAAACGTAGAAAAGAAATGAAAATGTCAGCAGATAAGTTGGCAGAAAAAATAGGTAA
AAATCGCGCAACAGTTTACAGATATGAAAAAGATGAAATAGAAAATATGCCTTACGATGTTTTAGAACCTATAGCAGAAG
CATTAAATGTTTCTCCCGCTTATCTTATGGGATGGGAAGAAAAAGAAAAAACTGAAACGGTAGCAGCACATTTGGATTAT
TCAGATTTAACAGAGGAGGAGCAAAAAGAAGTAGAGAATTTTATTGATTACATAAGAAACAGAAGAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References