Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4150930..4151446 Replicon chromosome
Accession NZ_CP092627
Organism Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011657

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag MJ899_RS20285 Protein ID WP_000220578.1
Coordinates 4150930..4151214 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag MJ899_RS20290 Protein ID WP_000212724.1
Coordinates 4151204..4151446 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ899_RS20270 (4146046) 4146046..4147698 + 1653 WP_000155049.1 alpha,alpha-phosphotrehalase -
MJ899_RS20275 (4148107) 4148107..4150245 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
MJ899_RS20280 (4150462) 4150462..4150926 + 465 WP_017465840.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MJ899_RS20285 (4150930) 4150930..4151214 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MJ899_RS20290 (4151204) 4151204..4151446 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MJ899_RS20295 (4151524) 4151524..4153437 - 1914 WP_001212135.1 BglG family transcription antiterminator -
MJ899_RS20300 (4153454) 4153454..4154194 - 741 WP_023193113.1 KDGP aldolase family protein -
MJ899_RS20305 (4154191) 4154191..4155309 - 1119 WP_017465839.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MJ899_RS20310 (4155293) 4155293..4156426 - 1134 WP_017465838.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T236750 WP_000220578.1 NZ_CP092627:c4151214-4150930 [Salmonella enterica subsp. enterica serovar Thompson]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T236750 NZ_LR735434:825551-825760 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT236750 WP_000212724.1 NZ_CP092627:c4151446-4151204 [Salmonella enterica subsp. enterica serovar Thompson]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT236750 NZ_LR735434:825251-825544 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References