Detailed information of TA system TA023675

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 3352690..3353210
• Replicon: chromosome
• Accession: NC_012483
• Organism: Acidobacterium capsulatum ATCC 51196

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C1F3U2
• Locus tag: ACP_RS13715
• Protein ID: WP_015897938.1
• Coordinates: 3352935..3353210 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ACP_RS13710
• Protein ID: WP_041839595.1
• Coordinates: 3352690..3352938 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACP_RS13670	3347972..3348244	+	273	WP_015897926.1	hypothetical protein	-
ACP_RS18140	3348318..3348467	+	150	WP_015897927.1	lmo0937 family membrane protein	-
ACP_RS13675	3348538..3349083	-	546	WP_015897928.1	adenine phosphoribosyltransferase	-
ACP_RS13680	3349091..3349372	-	282	WP_041839592.1	acylphosphatase	-
ACP_RS13685	3349490..3349873	-	384	WP_015897931.1	hypothetical protein	-
ACP_RS13690	3349852..3350265	-	414	WP_041839594.1	HEPN domain-containing protein	-
ACP_RS13695	3350338..3350898	-	561	WP_015897933.1	elongation factor P	-
ACP_RS13700	3351002..3351991	-	990	WP_052294822.1	hypothetical protein	-
ACP_RS13705	3351996..3352559	-	564	WP_015897936.1	aminodeoxychorismate/anthranilate synthase component II	-
ACP_RS13710	3352690..3352938	+	249	WP_041839595.1	ribbon-helix-helix protein, CopG family	Antitoxin
ACP_RS13715	3352935..3353210	+	276	WP_015897938.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ACP_RS13720	3353323..3354831	-	1509	WP_015897939.1	anthranilate synthase component I	-
ACP_RS13725	3355157..3356422	+	1266	WP_015897940.1	Glu/Leu/Phe/Val dehydrogenase	-
ACP_RS13735	3356824..3357207	+	384	WP_052294823.1	type II toxin-antitoxin system VapC family toxin	-
ACP_RS13740	3357311..3357964	+	654	WP_015897944.1	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10780.50 Da
• Isoelectric Point: 10.1300

>T23675 WP_015897938.1 NC_012483:3352935-3353210 [Acidobacterium capsulatum ATCC 51196]
MKLFWARPALKDAARLYEFIAADNPVIAANVLEGIRAGVTRLVQFPQLRERVDGYEPREVRRIYIGPYEVRYEIAEDAVR
ILRLWHARERR

Nucleotide

• Length: 276 bp

>T23675 NC_012483:3352935-3353210 [Acidobacterium capsulatum ATCC 51196]
ATGAAGCTCTTCTGGGCCAGGCCGGCGTTGAAAGACGCTGCCCGGCTGTACGAATTCATCGCTGCCGATAACCCCGTGAT
TGCGGCTAATGTGCTCGAAGGCATTCGAGCAGGCGTGACGCGTCTGGTGCAGTTTCCTCAGTTGAGGGAACGCGTCGATG
GGTATGAGCCTCGCGAAGTGAGACGAATTTATATCGGGCCATACGAAGTGCGCTACGAGATTGCAGAAGATGCGGTACGC
ATCCTTCGTCTGTGGCACGCCCGGGAGCGGCGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9168.60 Da
• Isoelectric Point: 6.2224

>AT23675 WP_041839595.1 NC_012483:3352690-3352938 [Acidobacterium capsulatum ATCC 51196]
MTAHVPTALAQRVDQLAAQLERPRGWVVKQALLAWVEEEELRHRMTLEGLAAADAGELVAHEEVEKWVRSLKTNKPLPPP
LA

Nucleotide

• Length: 249 bp

>AT23675 NC_012483:3352690-3352938 [Acidobacterium capsulatum ATCC 51196]
ATGACTGCGCATGTGCCCACGGCTCTGGCTCAGCGGGTCGATCAGCTTGCCGCGCAACTGGAACGTCCTCGCGGCTGGGT
TGTGAAGCAGGCACTGCTTGCATGGGTGGAAGAAGAAGAACTTCGCCACCGGATGACGCTGGAGGGACTGGCTGCGGCTG
ATGCAGGCGAATTGGTTGCGCATGAGGAAGTGGAGAAGTGGGTCCGCAGCCTGAAAACGAATAAGCCGCTTCCACCGCCT
CTCGCATGA

Structures

Toxin

• AlphaFold DB: C1F3U2