Detailed information of TA system TA236746

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3434333..3434953
• Replicon: chromosome
• Accession: NZ_CP092627
• Organism: Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011657

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: MJ899_RS16950
• Protein ID: WP_001280991.1
• Coordinates: 3434735..3434953 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: MJ899_RS16945
• Protein ID: WP_000344807.1
• Coordinates: 3434333..3434707 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ899_RS16935 (3429472)	3429472..3430665	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
MJ899_RS16940 (3430688)	3430688..3433837	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
MJ899_RS16945 (3434333)	3434333..3434707	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
MJ899_RS16950 (3434735)	3434735..3434953	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
MJ899_RS16955 (3435132)	3435132..3435683	+	552	WP_001278793.1	maltose O-acetyltransferase	-
MJ899_RS16960 (3435801)	3435801..3436271	+	471	WP_000136183.1	YlaC family protein	-
MJ899_RS16965 (3436327)	3436327..3436467	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
MJ899_RS16970 (3436473)	3436473..3436733	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
MJ899_RS16975 (3436958)	3436958..3438508	+	1551	WP_000213139.1	EAL domain-containing protein	-
MJ899_RS16985 (3438739)	3438739..3439128	+	390	WP_000961285.1	MGMT family protein	-
MJ899_RS16990 (3439161)	3439161..3439730	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T236746 WP_001280991.1 NZ_CP092627:3434735-3434953 [Salmonella enterica subsp. enterica serovar Thompson]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T236746 NZ_LR735432:891497-891859 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT236746 WP_000344807.1 NZ_CP092627:3434333-3434707 [Salmonella enterica subsp. enterica serovar Thompson]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT236746 NZ_LR735432:891330-891500 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTCCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0