236745

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2390829..2391351 Replicon chromosome
Accession NZ_CP092627
Organism Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011657

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag MJ899_RS11745 Protein ID WP_000221343.1
Coordinates 2391067..2391351 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MJ899_RS11740 Protein ID WP_000885424.1
Coordinates 2390829..2391077 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ899_RS11720 (2386550) 2386550..2387557 - 1008 WP_000201074.1 LacI family DNA-binding transcriptional regulator -
MJ899_RS11725 (2387815) 2387815..2389281 + 1467 WP_000987828.1 hypothetical protein -
MJ899_RS11730 (2389583) 2389583..2389873 + 291 WP_000742001.1 hypothetical protein -
MJ899_RS11735 (2390226) 2390226..2390681 + 456 Protein_2296 helix-turn-helix domain-containing protein -
MJ899_RS11740 (2390829) 2390829..2391077 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MJ899_RS11745 (2391067) 2391067..2391351 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MJ899_RS11750 (2391522) 2391522..2391911 + 390 WP_271232205.1 RidA family protein -
MJ899_RS11755 (2391963) 2391963..2393042 - 1080 WP_017465711.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MJ899_RS11760 (2393235) 2393235..2393723 - 489 WP_017465710.1 MarR family winged helix-turn-helix transcriptional regulator -
MJ899_RS11765 (2393768) 2393768..2395276 + 1509 WP_017465709.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2387818..2398133 10315


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T236745 WP_000221343.1 NZ_CP092627:2391067-2391351 [Salmonella enterica subsp. enterica serovar Thompson]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T236745 NZ_LR735432:880445-880654 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT236745 WP_000885424.1 NZ_CP092627:2390829-2391077 [Salmonella enterica subsp. enterica serovar Thompson]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT236745 NZ_LR735432:880145-880438 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References