Detailed information of TA system TA023674

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3310984..3311645
• Replicon: chromosome
• Accession: NC_012483
• Organism: Acidobacterium capsulatum ATCC 51196

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: C1F3P6
• Locus tag: ACP_RS13505
• Protein ID: WP_015897892.1
• Coordinates: 3310984..3311424 (-)
• Length: 147 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ACP_RS13510
• Protein ID: WP_015897893.1
• Coordinates: 3311421..3311645 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACP_RS13490	3307594..3309351	-	1758	WP_015897889.1	proline--tRNA ligase	-
ACP_RS13495	3309512..3310354	-	843	WP_015897890.1	hypothetical protein	-
ACP_RS13500	3310532..3310972	+	441	WP_041840322.1	acyl-CoA thioesterase	-
ACP_RS13505	3310984..3311424	-	441	WP_015897892.1	PIN domain-containing protein	Toxin
ACP_RS13510	3311421..3311645	-	225	WP_015897893.1	hypothetical protein	Antitoxin
ACP_RS13515	3311723..3312148	-	426	WP_015897894.1	cobalamin B12-binding domain-containing protein	-
ACP_RS13520	3312167..3313933	-	1767	WP_015897895.1	AAA family ATPase	-
ACP_RS13525	3314107..3315096	-	990	WP_015897896.1	polyprenyl synthetase family protein	-
ACP_RS13530	3315127..3315627	-	501	WP_015897897.1	YajQ family cyclic di-GMP-binding protein	-
ACP_RS13535	3315689..3316513	-	825	WP_169305982.1	TatD family hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-127)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 147 a.a.
• Molecular weight: 16394.75 Da
• Isoelectric Point: 9.3395

>T23674 WP_015897892.1 NC_012483:c3311424-3310984 [Acidobacterium capsulatum ATCC 51196]
MSVTLLDVNVLVAMFWPSHVHHVRAQQWFSEHSRHGWATCPLTQTGFVRIVSNPAFSKSAVTARDAIHVLQENLKHRSHV
FWADSVGVNEAASFTHDRLIGHKQVTDAYLIGLAHHHQGRLLTFDRGLGSLLPPALQKHSWIVCLS

Nucleotide

• Length: 441 bp

>T23674 NC_012483:c3311424-3310984 [Acidobacterium capsulatum ATCC 51196]
TTGAGCGTCACATTACTTGATGTCAACGTGCTGGTTGCTATGTTCTGGCCGTCACATGTTCATCATGTGCGAGCGCAACA
ATGGTTCAGCGAACACTCCAGGCATGGATGGGCGACCTGTCCGCTGACCCAGACAGGTTTTGTCCGCATCGTCTCGAATC
CAGCTTTCTCCAAAAGCGCCGTTACCGCGCGGGACGCGATCCATGTACTCCAAGAGAATCTGAAGCATCGCAGCCATGTC
TTCTGGGCAGATTCTGTGGGCGTGAACGAAGCCGCCTCATTCACTCATGACAGATTGATCGGCCACAAACAGGTCACAGA
CGCCTATCTGATTGGATTGGCCCACCACCATCAAGGCAGGCTGCTTACCTTCGACCGCGGCCTGGGCTCTCTGCTGCCTC
CAGCATTACAAAAGCACTCCTGGATCGTCTGCCTTTCGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8330.45 Da
• Isoelectric Point: 4.1964

>AT23674 WP_015897893.1 NC_012483:c3311645-3311421 [Acidobacterium capsulatum ATCC 51196]
MRTTLALDDDVFEEVRSYAEARDLPLGRAVTELLRRAMVQPAPTRRVNGLLVFDLPADSSPVTDEMVRDLESEI

Nucleotide

• Length: 225 bp

>AT23674 NC_012483:c3311645-3311421 [Acidobacterium capsulatum ATCC 51196]
ATGCGTACGACGCTTGCCTTGGATGATGATGTTTTTGAGGAAGTTCGCAGCTACGCCGAAGCTCGCGATCTTCCGTTGGG
GCGCGCCGTCACAGAGCTTTTGCGCCGCGCGATGGTGCAACCGGCACCTACGCGCCGTGTGAATGGGCTTCTGGTTTTTG
ATCTGCCCGCAGATAGTTCACCCGTCACGGACGAGATGGTTCGCGATCTGGAATCTGAGATTTGA

Structures

Toxin

• AlphaFold DB: C1F3P6