236734

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834530..835190 Replicon chromosome
Accession NZ_CP092627
Organism Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011657

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag MJ899_RS04020 Protein ID WP_000244756.1
Coordinates 834777..835190 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MJ899_RS04015 Protein ID WP_000351186.1
Coordinates 834530..834796 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ899_RS03995 (830457) 830457..831890 - 1434 WP_017465472.1 6-phospho-beta-glucosidase BglA -
MJ899_RS04000 (832049) 832049..832360 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MJ899_RS04005 (832525) 832525..833184 + 660 WP_000250289.1 hemolysin III family protein -
MJ899_RS04010 (833300) 833300..834280 - 981 WP_000874178.1 tRNA-modifying protein YgfZ -
MJ899_RS04015 (834530) 834530..834796 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MJ899_RS04020 (834777) 834777..835190 + 414 WP_000244756.1 protein YgfX Toxin
MJ899_RS04025 (835243) 835243..835764 - 522 WP_001055885.1 flavodoxin FldB -
MJ899_RS04030 (835877) 835877..836773 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MJ899_RS04035 (836797) 836797..837510 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MJ899_RS04040 (837516) 837516..839249 + 1734 WP_017465473.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T236734 WP_000244756.1 NZ_CP092627:834777-835190 [Salmonella enterica subsp. enterica serovar Thompson]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T236734 NZ_LR723670:3877921-3878343 [Rhizobium flavum]
TTGAGATATCTGCTCGACACAAACGTTGTCTCTGAGCTCCGTAAGGTTGGGGACGGTAAAGCTGATCAGAACGTGACGGC
TTGGATAAGCGCGCAGGACTCCCGAGATCTGTATATTTCTGCCATAACAATTCTAGAACTTGAGCGCGGGATACTCAGCA
TCCAGCGGCGTGACATTGAGCAGGGCGCTCGCTTACGAGCCTGGATGGATAGCCGAGTACGCCCGGAGTTCGCTCAGCGC
ATCGTCGCTATCGACGAAGCGATTGCGACGCGATGTGCCCATTTGCATATTCCGGATCGCCGCAACGAAGCTGATGCACT
CATCGCTGCCACGGCAGTCGTGCACGGGCTTGTGGTCGTTACACGCAACACTCAAGATTTCCAGGGCACCGGGGTTATCC
TCGTGGACCCATGGCGTTCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT236734 WP_000351186.1 NZ_CP092627:834530-834796 [Salmonella enterica subsp. enterica serovar Thompson]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT236734 NZ_LR723670:3878469-3878723 [Rhizobium flavum]
ATGGCGACGATGAATGTATCCCTGCCGGACCCCATGAAAGACTGGGTTGAAGCACAAGCCAAGACGGGTCGATATTCAAA
CGTAAGCGATTACGTCAGGGACCTAATCCGCAGAGACCAGGCTCGTACGCACAAGATTGCCCAGATGCAGCGGTTTGTCG
ACGACGGGATCACAAGTGGGTTGGGGCGTCGTTCAAAGGACGAGCTGTTTGCTGCAGCAACCGAGCTAGCTGAGATCAGC
CGCGGACGTGCTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5


Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References