Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 834530..835190 | Replicon | chromosome |
Accession | NZ_CP092627 | ||
Organism | Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011657 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | Q57K70 |
Locus tag | MJ899_RS04020 | Protein ID | WP_000244756.1 |
Coordinates | 834777..835190 (+) | Length | 138 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | S5MU13 |
Locus tag | MJ899_RS04015 | Protein ID | WP_000351186.1 |
Coordinates | 834530..834796 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MJ899_RS03995 (830457) | 830457..831890 | - | 1434 | WP_017465472.1 | 6-phospho-beta-glucosidase BglA | - |
MJ899_RS04000 (832049) | 832049..832360 | + | 312 | WP_001182976.1 | N(4)-acetylcytidine aminohydrolase | - |
MJ899_RS04005 (832525) | 832525..833184 | + | 660 | WP_000250289.1 | hemolysin III family protein | - |
MJ899_RS04010 (833300) | 833300..834280 | - | 981 | WP_000874178.1 | tRNA-modifying protein YgfZ | - |
MJ899_RS04015 (834530) | 834530..834796 | + | 267 | WP_000351186.1 | FAD assembly factor SdhE | Antitoxin |
MJ899_RS04020 (834777) | 834777..835190 | + | 414 | WP_000244756.1 | protein YgfX | Toxin |
MJ899_RS04025 (835243) | 835243..835764 | - | 522 | WP_001055885.1 | flavodoxin FldB | - |
MJ899_RS04030 (835877) | 835877..836773 | + | 897 | WP_000434302.1 | site-specific tyrosine recombinase XerD | - |
MJ899_RS04035 (836797) | 836797..837510 | + | 714 | WP_000745614.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
MJ899_RS04040 (837516) | 837516..839249 | + | 1734 | WP_017465473.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 16183.15 Da Isoelectric Point: 10.7537
>T236734 WP_000244756.1 NZ_CP092627:834777-835190 [Salmonella enterica subsp. enterica serovar Thompson]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH
Download Length: 414 bp
>T236734 NZ_LR723670:3877921-3878343 [Rhizobium flavum]
TTGAGATATCTGCTCGACACAAACGTTGTCTCTGAGCTCCGTAAGGTTGGGGACGGTAAAGCTGATCAGAACGTGACGGC
TTGGATAAGCGCGCAGGACTCCCGAGATCTGTATATTTCTGCCATAACAATTCTAGAACTTGAGCGCGGGATACTCAGCA
TCCAGCGGCGTGACATTGAGCAGGGCGCTCGCTTACGAGCCTGGATGGATAGCCGAGTACGCCCGGAGTTCGCTCAGCGC
ATCGTCGCTATCGACGAAGCGATTGCGACGCGATGTGCCCATTTGCATATTCCGGATCGCCGCAACGAAGCTGATGCACT
CATCGCTGCCACGGCAGTCGTGCACGGGCTTGTGGTCGTTACACGCAACACTCAAGATTTCCAGGGCACCGGGGTTATCC
TCGTGGACCCATGGCGTTCCTGA
TTGAGATATCTGCTCGACACAAACGTTGTCTCTGAGCTCCGTAAGGTTGGGGACGGTAAAGCTGATCAGAACGTGACGGC
TTGGATAAGCGCGCAGGACTCCCGAGATCTGTATATTTCTGCCATAACAATTCTAGAACTTGAGCGCGGGATACTCAGCA
TCCAGCGGCGTGACATTGAGCAGGGCGCTCGCTTACGAGCCTGGATGGATAGCCGAGTACGCCCGGAGTTCGCTCAGCGC
ATCGTCGCTATCGACGAAGCGATTGCGACGCGATGTGCCCATTTGCATATTCCGGATCGCCGCAACGAAGCTGATGCACT
CATCGCTGCCACGGCAGTCGTGCACGGGCTTGTGGTCGTTACACGCAACACTCAAGATTTCCAGGGCACCGGGGTTATCC
TCGTGGACCCATGGCGTTCCTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10550.05 Da Isoelectric Point: 6.0783
>AT236734 WP_000351186.1 NZ_CP092627:834530-834796 [Salmonella enterica subsp. enterica serovar Thompson]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT236734 NZ_LR723670:3878469-3878723 [Rhizobium flavum]
ATGGCGACGATGAATGTATCCCTGCCGGACCCCATGAAAGACTGGGTTGAAGCACAAGCCAAGACGGGTCGATATTCAAA
CGTAAGCGATTACGTCAGGGACCTAATCCGCAGAGACCAGGCTCGTACGCACAAGATTGCCCAGATGCAGCGGTTTGTCG
ACGACGGGATCACAAGTGGGTTGGGGCGTCGTTCAAAGGACGAGCTGTTTGCTGCAGCAACCGAGCTAGCTGAGATCAGC
CGCGGACGTGCTTGA
ATGGCGACGATGAATGTATCCCTGCCGGACCCCATGAAAGACTGGGTTGAAGCACAAGCCAAGACGGGTCGATATTCAAA
CGTAAGCGATTACGTCAGGGACCTAATCCGCAGAGACCAGGCTCGTACGCACAAGATTGCCCAGATGCAGCGGTTTGTCG
ACGACGGGATCACAAGTGGGTTGGGGCGTCGTTCAAAGGACGAGCTGTTTGCTGCAGCAACCGAGCTAGCTGAGATCAGC
CGCGGACGTGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3Z1E9V5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5I0YWH4 |