Detailed information of TA system TA236733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 315219..315805
• Replicon: chromosome
• Accession: NZ_CP092627
• Organism: Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011657

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A5V1HI31
• Locus tag: MJ899_RS01445
• Protein ID: WP_000174965.1
• Coordinates: 315437..315805 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A8F2ZY79
• Locus tag: MJ899_RS01440
• Protein ID: WP_001599562.1
• Coordinates: 315219..315440 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ899_RS01415 (310239)	310239..311348	+	1110	WP_000822976.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
MJ899_RS01420 (311408)	311408..312334	+	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
MJ899_RS01425 (312331)	312331..313608	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
MJ899_RS01430 (313605)	313605..314372	+	768	WP_017465331.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
MJ899_RS01435 (314374)	314374..315087	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
MJ899_RS01440 (315219)	315219..315440	+	222	WP_001599562.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MJ899_RS01445 (315437)	315437..315805	+	369	WP_000174965.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
MJ899_RS01450 (316064)	316064..317380	+	1317	WP_017465332.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
MJ899_RS01455 (317485)	317485..318372	+	888	WP_000094074.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
MJ899_RS01460 (318369)	318369..319214	+	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
MJ899_RS01465 (319216)	319216..320286	+	1071	WP_000907838.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	312331..321023	8692

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (24-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13599.89 Da
• Isoelectric Point: 6.4657

>T236733 WP_000174965.1 NZ_CP092627:315437-315805 [Salmonella enterica subsp. enterica serovar Thompson]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGYIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Nucleotide

• Length: 369 bp

>T236733 NZ_LR723670:c2415429-2415148 [Rhizobium flavum]
TTGATCCGCACATTTCGGGATGCCCTCACACGATCGATTGCTGACGGCAGTGTGAAGAAGGGATTTCCGTCTGATCTCGT
GCGCCGCGCCCAGCTGCTCCTCACGGTGCTGGACGCAGCAGTATCGCTGGAGGACCTACGCTCGCCTCCTGGTAACAGGT
TGGAGAAGCTGAGCGGCGACAGAGCCGCCCAGCACTCTATCCGCATTAACAAGCAGTGGCGGATCTGCTTCATCTGGACA
GATGCCGGCGCGGAAGACGTGGAAATCGTCGATTATCACTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8151.20 Da
• Isoelectric Point: 6.4643

>AT236733 WP_001599562.1 NZ_CP092627:315219-315440 [Salmonella enterica subsp. enterica serovar Thompson]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRKLADK

Nucleotide

• Length: 222 bp

>AT236733 NZ_LR723670:c2415121-2414819 [Rhizobium flavum]
ATGAGTTCGACCGATTTGCCTCCTGTTCATCCGGGAGAAATCCTTCGGGACCTGTATCTCGAGCCACTCGACATGTCCCC
CTATGCGCTTGCCAAGAAGCTTCACGTCCCTCGCACTCGGATCGAGAGAATAGTCGCGCAGAAGACCAGCGTAACGCCGG
ATACTGCCCTGCGTCTTGCAAGGTTCTTCAAAACAACGCCGGAGTTCTGGATGAATCTGCAAAACGGCTTTGACCTGAAG
CTCGAGGCGGATGCACTCAAGGATGAGTTGGAAGAAATAGCAGCCTATGAAGCCGCGGCCTAA

Structures

Toxin

• AlphaFold DB: A0A5V1HI31