Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4889955..4891636 Replicon chromosome
Accession NZ_CP092589
Organism Klebsiella pneumoniae strain EFN 299

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag MKT41_RS24110 Protein ID WP_002885155.1
Coordinates 4889955..4890872 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag MKT41_RS24115 Protein ID WP_004151732.1
Coordinates 4890878..4891636 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKT41_RS24090 (MKT41_24080) 4885261..4886781 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
MKT41_RS24095 (MKT41_24085) 4886778..4887776 + 999 WP_002885172.1 ribose ABC transporter permease -
MKT41_RS24100 (MKT41_24090) 4887807..4888748 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
MKT41_RS24105 (MKT41_24095) 4888823..4889830 + 1008 WP_004151731.1 carbohydrate kinase family protein -
MKT41_RS24110 (MKT41_24100) 4889955..4890872 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
MKT41_RS24115 (MKT41_24105) 4890878..4891636 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
MKT41_RS24120 (MKT41_24110) 4891722..4892450 - 729 WP_002885152.1 response regulator transcription factor -
MKT41_RS24125 (MKT41_24115) 4892723..4894870 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
MKT41_RS24130 (MKT41_24120) 4895100..4895786 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T236726 WP_002885155.1 NZ_CP092589:c4890872-4889955 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T236726 NZ_LR699570:c3105722-3105330 [Mycobacterium tuberculosis variant bovis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGGCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT236726 WP_004151732.1 NZ_CP092589:c4891636-4890878 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT236726 NZ_LR699570:c3105934-3105719 [Mycobacterium tuberculosis variant bovis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References