Detailed information of TA system TA023672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 2549622..2550198
• Replicon: chromosome
• Accession: NC_012483
• Organism: Acidobacterium capsulatum ATCC 51196

Toxin (Protein)

• Gene name: parE
• Uniprot ID: C1F9M8
• Locus tag: ACP_RS10420
• Protein ID: WP_015897284.1
• Coordinates: 2549878..2550198 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: C1F9M7
• Locus tag: ACP_RS10415
• Protein ID: WP_015897283.1
• Coordinates: 2549622..2549885 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ACP_RS10390	2545640..2546224	+	585	WP_041839490.1	hypothetical protein	-
ACP_RS10395	2546254..2547240	+	987	WP_041840187.1	alpha/beta hydrolase	-
ACP_RS10400	2547290..2548786	-	1497	WP_052294782.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
ACP_RS10405	2548815..2549375	-	561	WP_148215122.1	single-stranded DNA-binding protein	-
ACP_RS10415	2549622..2549885	+	264	WP_015897283.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
ACP_RS10420	2549878..2550198	+	321	WP_015897284.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ACP_RS10425	2550353..2551342	-	990	WP_015897285.1	porphobilinogen synthase	-
ACP_RS10430	2551388..2551891	-	504	WP_015897286.1	zinc ribbon domain-containing protein	-
ACP_RS10435	2551932..2552414	-	483	WP_083770581.1	Holliday junction resolvase RuvX	-
ACP_RS10440	2552514..2553548	+	1035	WP_015897288.1	endolytic transglycosylase MltG	-
ACP_RS10445	2553639..2554532	+	894	WP_015897289.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-98)

Antitoxin

• Antitoxin ParD (6-72)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12390.25 Da
• Isoelectric Point: 10.1352

>T23672 WP_015897284.1 NC_012483:2549878-2550198 [Acidobacterium capsulatum ATCC 51196]
VADYRLSRLALADLKAIALYTRQTWGLAQAQQYLAELEEMILRLASNSHLGRACDEIRKGYRRIEQRRHVLFYRVRRSSR
SAQSETVEIIRILHARMLPGEHLGEE

Nucleotide

• Length: 321 bp

>T23672 NC_012483:2549878-2550198 [Acidobacterium capsulatum ATCC 51196]
GTGGCTGATTACAGGCTCTCCCGGCTTGCCCTGGCCGATCTCAAGGCGATCGCTCTCTACACCCGGCAAACGTGGGGCCT
GGCACAGGCGCAACAATATCTCGCGGAGCTGGAGGAGATGATTCTGCGGCTGGCGTCGAACTCCCATCTGGGCAGAGCCT
GCGATGAGATTCGTAAAGGCTATCGGCGCATCGAGCAGCGCCGTCATGTCCTCTTTTATCGCGTTCGCCGCTCTTCCCGG
TCCGCGCAAAGCGAGACGGTCGAAATCATTCGCATTCTGCATGCGCGCATGTTGCCCGGCGAACACCTCGGCGAAGAATA
A

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9704.88 Da
• Isoelectric Point: 4.8898

>AT23672 WP_015897283.1 NC_012483:2549622-2549885 [Acidobacterium capsulatum ATCC 51196]
MPTRNINLTPQMDRFVDSRIKEGRYGNASEVIRAGLRALEKEEREEEARIEALRSALVAGEQSGFVTGNPFEQVREFLND
LPKAAGG

Nucleotide

• Length: 264 bp

>AT23672 NC_012483:2549622-2549885 [Acidobacterium capsulatum ATCC 51196]
ATGCCCACTCGCAATATCAATCTCACTCCGCAGATGGATCGCTTTGTCGATTCCCGGATCAAAGAAGGCCGCTATGGCAA
TGCCAGCGAGGTCATTCGCGCCGGTCTGCGCGCGCTTGAAAAGGAGGAGCGGGAAGAGGAAGCCCGGATTGAAGCACTTC
GCTCGGCCCTGGTTGCGGGAGAGCAAAGCGGCTTTGTTACGGGAAACCCCTTCGAGCAAGTCCGGGAGTTTCTGAACGAT
TTGCCGAAGGCTGCGGGTGGCTGA

Structures

Toxin

• AlphaFold DB: C1F9M8

Antitoxin

• AlphaFold DB: C1F9M7