Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2392955..2393930 Replicon chromosome
Accession NC_012472
Organism Bacillus cereus 03BB102

Toxin (Protein)


Gene name spoIISA Uniprot ID C2NHW3
Locus tag BCA_RS13425 Protein ID WP_002002796.1
Coordinates 2392955..2393692 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag BCA_RS13430 Protein ID WP_000588712.1
Coordinates 2393805..2393930 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCA_RS13400 2388447..2389148 + 702 WP_001294994.1 hypothetical protein -
BCA_RS13405 2389276..2390160 + 885 WP_000795511.1 hypothetical protein -
BCA_RS13410 2390468..2391272 - 805 Protein_2367 alpha-keto acid decarboxylase family protein -
BCA_RS13415 2391379..2391861 + 483 WP_000191909.1 MarR family winged helix-turn-helix transcriptional regulator -
BCA_RS13420 2392029..2392766 + 738 WP_000594157.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
BCA_RS13425 2392955..2393692 + 738 WP_002002796.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
BCA_RS13430 2393805..2393930 + 126 WP_000588712.1 hypothetical protein Antitoxin
BCA_RS13440 2394219..2394500 - 282 WP_001041554.1 hypothetical protein -
BCA_RS13445 2394780..2395016 - 237 WP_001021690.1 hypothetical protein -
BCA_RS30610 2395355..2395531 + 177 WP_000852618.1 hypothetical protein -
BCA_RS13455 2395675..2397144 + 1470 WP_000287550.1 beta-Ala-His dipeptidase -
BCA_RS13460 2397730..2398200 - 471 WP_000771846.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28283.98 Da        Isoelectric Point: 8.2998

>T23671 WP_002002796.1 NC_012472:2392955-2393692 [Bacillus cereus 03BB102]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNAAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTTFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T23671 NC_012472:2392955-2393692 [Bacillus cereus 03BB102]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGATTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAGATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATGCAGCAGTATTTGGTACGATGG
AATGGCATACGGAAGAAGAATATACAAAAAGTTTAAACGCATTTTTAGATTCATATGGGGAAAAGATTGGGGCGAAGATT
GTTGTATTTGAAGCAGCAAAGGAATTAAATACAACCTTTCGCGGTATCCGCTCGCAATTTAGTATTATCGTTCCGTTTGA
ACACATTGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTTATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT23671 WP_000588712.1 NC_012472:2393805-2393930 [Bacillus cereus 03BB102]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT23671 NC_012472:2393805-2393930 [Bacillus cereus 03BB102]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
GTTACAGCAAGTAGAAGAGTTAGAAGAAGAGTTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D3YFM0

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References