Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 939291..939943 Replicon chromosome
Accession NZ_CP092588
Organism Vibrio gazogenes strain PB1

Toxin (Protein)


Gene name hicA Uniprot ID A0A1M4UZZ3
Locus tag MKS89_RS19835 Protein ID WP_072955385.1
Coordinates 939764..939943 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1M4V002
Locus tag MKS89_RS19830 Protein ID WP_021021012.1
Coordinates 939291..939704 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKS89_RS19805 (MKS89_19825) 935625..935954 - 330 WP_072955392.1 hypothetical protein -
MKS89_RS19810 (MKS89_19830) 936196..937251 + 1056 WP_072955391.1 IS630 family transposase -
MKS89_RS19815 (MKS89_19835) 937271..937843 - 573 WP_131814860.1 hypothetical protein -
MKS89_RS19820 (MKS89_19840) 937982..938308 - 327 WP_072955387.1 hypothetical protein -
MKS89_RS19825 (MKS89_19845) 938455..939003 - 549 WP_072955735.1 hypothetical protein -
MKS89_RS19830 (MKS89_19850) 939291..939704 - 414 WP_021021012.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MKS89_RS19835 (MKS89_19855) 939764..939943 - 180 WP_072955385.1 type II toxin-antitoxin system HicA family toxin Toxin
MKS89_RS19840 (MKS89_19860) 940346..940627 - 282 WP_205409164.1 hypothetical protein -
MKS89_RS20920 941297..942973 - 1677 WP_077316466.1 glycoside hydrolase family 11 protein -
MKS89_RS19855 (MKS89_19875) 944020..944310 - 291 WP_072955382.1 YkgJ family cysteine cluster protein -
MKS89_RS19860 (MKS89_19880) 944467..944670 - 204 WP_021021019.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 936349..937251 902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6679.92 Da        Isoelectric Point: 11.0775

>T236709 WP_072955385.1 NZ_CP092588:c939943-939764 [Vibrio gazogenes]
VKSADLINLLKKNGWELVSVRGSHHKFRHLAHDDPIIVPHPKKDLKIGLVNKIKRQAGL

Download         Length: 180 bp

>T236709 NZ_LR699570:c2213628-2213209 [Mycobacterium tuberculosis variant bovis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15259.33 Da        Isoelectric Point: 4.5544

>AT236709 WP_021021012.1 NZ_CP092588:c939704-939291 [Vibrio gazogenes]
MLYPIAIDTGDKEHAYGVTFPDLPGCFSAGDTLDEALLNAKDAAEFYLEDLAEHGKLPPKAGDLSTWQKDPEYLGWAWAV
VDIDVEPFLGKSIKINATLPTLYLKKIDDLVKVHPEYKNRSHFLQIAATHEFEKLAG

Download         Length: 414 bp

>AT236709 NZ_LR699570:c2213897-2213637 [Mycobacterium tuberculosis variant bovis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4UZZ3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4V002

References