Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 924980..925496 Replicon chromosome
Accession NZ_CP092588
Organism Vibrio gazogenes strain PB1

Toxin (Protein)


Gene name relB Uniprot ID A0A1M4V2Z8
Locus tag MKS89_RS19740 Protein ID WP_072955412.1
Coordinates 924980..925249 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1M4V2U4
Locus tag MKS89_RS19745 Protein ID WP_072955410.1
Coordinates 925242..925496 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKS89_RS19710 (MKS89_19730) 920158..920841 - 684 WP_131814862.1 hypothetical protein -
MKS89_RS19715 (MKS89_19735) 920973..921392 - 420 WP_235862468.1 hypothetical protein -
MKS89_RS19720 (MKS89_19740) 921603..921932 - 330 WP_235862469.1 hypothetical protein -
MKS89_RS19725 (MKS89_19745) 922576..923457 - 882 WP_072955738.1 HEPN domain-containing protein -
MKS89_RS19730 (MKS89_19750) 923735..924232 - 498 WP_021020996.1 GNAT family N-acetyltransferase -
MKS89_RS19735 (MKS89_19755) 924335..924838 - 504 WP_072955414.1 peptide deformylase -
MKS89_RS19740 (MKS89_19760) 924980..925249 - 270 WP_072955412.1 Txe/YoeB family addiction module toxin Toxin
MKS89_RS19745 (MKS89_19765) 925242..925496 - 255 WP_072955410.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MKS89_RS19750 (MKS89_19770) 925644..926099 - 456 WP_072955408.1 hypothetical protein -
MKS89_RS19755 (MKS89_19775) 926221..926358 + 138 Protein_814 IS256 family transposase -
MKS89_RS19760 (MKS89_19780) 926390..927334 - 945 WP_072955406.1 DUF5677 domain-containing protein -
MKS89_RS19765 (MKS89_19785) 927902..928084 - 183 WP_072955404.1 hypothetical protein -
MKS89_RS19770 (MKS89_19790) 928404..929456 - 1053 WP_072955398.1 DctP family TRAP transporter solute-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 918370..939075 20705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10656.06 Da        Isoelectric Point: 9.4079

>T236708 WP_072955412.1 NZ_CP092588:c925249-924980 [Vibrio gazogenes]
MSSSQRLLSWTDESWNDYLYWRTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T236708 NZ_LR699570:c2204491-2204195 [Mycobacterium tuberculosis variant bovis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9444.56 Da        Isoelectric Point: 4.5700

>AT236708 WP_072955410.1 NZ_CP092588:c925496-925242 [Vibrio gazogenes]
MKIVSFTEARNSLKAVLDGVVNDADTTVITRRDAEDAVVMSLDYYNSLMETVHLLRSPENAEHLNRSIAQYRAGQTTARD
LMDE

Download         Length: 255 bp

>AT236708 NZ_LR699570:c2204739-2204488 [Mycobacterium tuberculosis variant bovis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4V2Z8

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4V2U4

References