Detailed information of TA system TA236706

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 340609..341147
• Replicon: chromosome
• Accession: NZ_CP092588
• Organism: Vibrio gazogenes strain PB1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A1M4TJ95
• Locus tag: MKS89_RS17125
• Protein ID: WP_072954745.1
• Coordinates: 340848..341147 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1M4TJ42
• Locus tag: MKS89_RS17120
• Protein ID: WP_072954743.1
• Coordinates: 340609..340851 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKS89_RS17100 (MKS89_17120)	335643..336557	-	915	WP_205409103.1	homocysteine S-methyltransferase family protein	-
MKS89_RS17105 (MKS89_17125)	336794..337321	+	528	WP_072954737.1	PAS domain-containing protein	-
MKS89_RS17110 (MKS89_17130)	337331..338815	+	1485	WP_077316224.1	methyl-accepting chemotaxis protein	-
MKS89_RS17115 (MKS89_17135)	338983..340203	-	1221	WP_072954740.1	aldose 1-epimerase family protein	-
MKS89_RS17120 (MKS89_17140)	340609..340851	+	243	WP_072954743.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
MKS89_RS17125 (MKS89_17145)	340848..341147	+	300	WP_072954745.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MKS89_RS17130 (MKS89_17150)	341181..341492	-	312	WP_072954747.1	antibiotic biosynthesis monooxygenase family protein	-
MKS89_RS17135 (MKS89_17155)	341629..341829	+	201	Protein_296	IS110 family transposase	-
MKS89_RS17140 (MKS89_17160)	342196..342798	-	603	WP_072954750.1	nitroreductase family protein	-
MKS89_RS17145 (MKS89_17165)	342943..343833	+	891	WP_072954753.1	LysR family transcriptional regulator	-
MKS89_RS17150 (MKS89_17170)	343950..344144	-	195	WP_131814842.1	hypothetical protein	-
MKS89_RS17155 (MKS89_17175)	344607..345653	-	1047	WP_131814844.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	340609..351740	11131
	-	flank	IS/Tn	-	-	341629..341874	245

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11719.39 Da
• Isoelectric Point: 9.7945

>T236706 WP_072954745.1 NZ_CP092588:340848-341147 [Vibrio gazogenes]
MKPFQLTNRAKSDLKDIALFTYHRWGREQRNAYVKQFDETFWLLAENPDIGKNCDEIRNGYKKFPQGSHVIFYQQISSQN
IQIIRILHKSMDVNPIFGA

Nucleotide

• Length: 300 bp

>T236706 NZ_LR699570:c2195487-2195158 [Mycobacterium tuberculosis variant bovis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8982.96 Da
• Isoelectric Point: 4.3219

>AT236706 WP_072954743.1 NZ_CP092588:340609-340851 [Vibrio gazogenes]
MAKNTSITLGEHFDSFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGLADYDLNSFINELDSEEKK

Nucleotide

• Length: 243 bp

>AT236706 NZ_LR699570:c2195861-2195484 [Mycobacterium tuberculosis variant bovis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Structures

Toxin

• AlphaFold DB: A0A1M4TJ95

Antitoxin

• AlphaFold DB: A0A1M4TJ42