Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 281013..281572 Replicon chromosome
Accession NZ_CP092588
Organism Vibrio gazogenes strain PB1

Toxin (Protein)


Gene name relE Uniprot ID A0A1M4TBS6
Locus tag MKS89_RS16860 Protein ID WP_072954617.1
Coordinates 281013..281291 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1M4TC76
Locus tag MKS89_RS16865 Protein ID WP_072954620.1
Coordinates 281288..281572 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKS89_RS16840 (MKS89_16860) 276799..278256 + 1458 WP_072954604.1 family 1 glycosylhydrolase -
MKS89_RS16845 (MKS89_16865) 278483..278869 - 387 WP_072954607.1 DUF5405 family protein -
MKS89_RS16850 (MKS89_16870) 278989..279492 - 504 WP_072954610.1 GNAT family N-acetyltransferase -
MKS89_RS16855 (MKS89_16875) 279539..280147 - 609 WP_072954612.1 MarC family protein -
MKS89_RS16860 (MKS89_16880) 281013..281291 - 279 WP_072954617.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
MKS89_RS16865 (MKS89_16885) 281288..281572 - 285 WP_072954620.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MKS89_RS16870 (MKS89_16890) 281962..282477 + 516 WP_072954622.1 adenylate kinase -
MKS89_RS16875 (MKS89_16895) 282528..282668 + 141 Protein_244 VOC family protein -
MKS89_RS16880 (MKS89_16900) 282862..284199 + 1338 WP_235862461.1 MATE family efflux transporter -
MKS89_RS16885 (MKS89_16905) 284309..284923 + 615 WP_072954624.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-73)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10821.39 Da        Isoelectric Point: 4.2894

>T236705 WP_072954617.1 NZ_CP092588:c281291-281013 [Vibrio gazogenes]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLSISEISMIVSYWVEGDIVHVM
RVLHQKQKFPAE

Download         Length: 279 bp

>T236705 NZ_LR699570:1959352-1959600 [Mycobacterium tuberculosis variant bovis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10912.27 Da        Isoelectric Point: 9.9593

>AT236705 WP_072954620.1 NZ_CP092588:c281572-281288 [Vibrio gazogenes]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTDQVNLAFEKFDSGKAVFTDHNAAKSR
MTERKAKIRNRGKL

Download         Length: 285 bp

>AT236705 NZ_LR699570:1959140-1959352 [Mycobacterium tuberculosis variant bovis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4TBS6

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4TC76

References