Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 2700751..2701270 Replicon chromosome
Accession NZ_CP092581
Organism Staphylococcus aureus strain VRMSSA-WC111

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag MKI52_RS13560 Protein ID WP_000588503.1
Coordinates 2701013..2701270 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag MKI52_RS13555 Protein ID WP_000388479.1
Coordinates 2700751..2701020 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI52_RS13525 (MKI52_002680) 2696322..2696738 - 417 WP_001232859.1 hypothetical protein -
MKI52_RS13530 (MKI52_002681) 2696741..2697025 - 285 WP_000353844.1 hypothetical protein -
MKI52_RS13535 (MKI52_002682) 2697391..2697615 + 225 WP_000410576.1 hypothetical protein -
MKI52_RS14585 (MKI52_002683) 2697917..2698003 - 87 WP_125669474.1 type I toxin-antitoxin system Fst family toxin -
MKI52_RS13540 (MKI52_002684) 2698738..2699418 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
MKI52_RS13545 (MKI52_002685) 2699764..2700060 + 297 WP_200857964.1 hypothetical protein -
MKI52_RS13550 (MKI52_002686) 2700441..2700620 + 180 WP_001120991.1 hypothetical protein -
MKI52_RS13555 (MKI52_002687) 2700751..2701020 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI52_RS13560 (MKI52_002688) 2701013..2701270 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
MKI52_RS13565 (MKI52_002689) 2701907..2702731 + 825 WP_001809248.1 hypothetical protein -
MKI52_RS13570 (MKI52_002690) 2702896..2703510 - 615 WP_001261742.1 recombinase family protein -
MKI52_RS13575 (MKI52_002691) 2703960..2705285 + 1326 WP_000969590.1 Y-family DNA polymerase -
MKI52_RS13580 (MKI52_002692) 2705278..2705628 + 351 WP_000568378.1 hypothetical protein -
MKI52_RS13585 (MKI52_002693) 2705625..2705804 + 180 WP_001021554.1 hypothetical protein -
MKI52_RS13590 (MKI52_002694) 2705940..2706230 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage msr(A) / mph(C) / aph(3')-III / tet(S) / aac(6')-aph(2'') / VanHAX / erm(B) - 2616271..2713986 97715


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T236704 WP_000588503.1 NZ_CP092581:2701013-2701270 [Staphylococcus aureus]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T236704 NZ_LR699570:c1938913-1938524 [Mycobacterium tuberculosis variant bovis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT236704 WP_000388479.1 NZ_CP092581:2700751-2701020 [Staphylococcus aureus]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT236704 NZ_LR699570:c1939137-1938910 [Mycobacterium tuberculosis variant bovis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References