Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 2700751..2701270 | Replicon | chromosome |
Accession | NZ_CP092581 | ||
Organism | Staphylococcus aureus strain VRMSSA-WC111 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | MKI52_RS13560 | Protein ID | WP_000588503.1 |
Coordinates | 2701013..2701270 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | MKI52_RS13555 | Protein ID | WP_000388479.1 |
Coordinates | 2700751..2701020 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MKI52_RS13525 (MKI52_002680) | 2696322..2696738 | - | 417 | WP_001232859.1 | hypothetical protein | - |
MKI52_RS13530 (MKI52_002681) | 2696741..2697025 | - | 285 | WP_000353844.1 | hypothetical protein | - |
MKI52_RS13535 (MKI52_002682) | 2697391..2697615 | + | 225 | WP_000410576.1 | hypothetical protein | - |
MKI52_RS14585 (MKI52_002683) | 2697917..2698003 | - | 87 | WP_125669474.1 | type I toxin-antitoxin system Fst family toxin | - |
MKI52_RS13540 (MKI52_002684) | 2698738..2699418 | - | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
MKI52_RS13545 (MKI52_002685) | 2699764..2700060 | + | 297 | WP_200857964.1 | hypothetical protein | - |
MKI52_RS13550 (MKI52_002686) | 2700441..2700620 | + | 180 | WP_001120991.1 | hypothetical protein | - |
MKI52_RS13555 (MKI52_002687) | 2700751..2701020 | + | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
MKI52_RS13560 (MKI52_002688) | 2701013..2701270 | + | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
MKI52_RS13565 (MKI52_002689) | 2701907..2702731 | + | 825 | WP_001809248.1 | hypothetical protein | - |
MKI52_RS13570 (MKI52_002690) | 2702896..2703510 | - | 615 | WP_001261742.1 | recombinase family protein | - |
MKI52_RS13575 (MKI52_002691) | 2703960..2705285 | + | 1326 | WP_000969590.1 | Y-family DNA polymerase | - |
MKI52_RS13580 (MKI52_002692) | 2705278..2705628 | + | 351 | WP_000568378.1 | hypothetical protein | - |
MKI52_RS13585 (MKI52_002693) | 2705625..2705804 | + | 180 | WP_001021554.1 | hypothetical protein | - |
MKI52_RS13590 (MKI52_002694) | 2705940..2706230 | + | 291 | WP_000026576.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | msr(A) / mph(C) / aph(3')-III / tet(S) / aac(6')-aph(2'') / VanHAX / erm(B) | - | 2616271..2713986 | 97715 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T236704 WP_000588503.1 NZ_CP092581:2701013-2701270 [Staphylococcus aureus]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T236704 NZ_LR699570:c1938913-1938524 [Mycobacterium tuberculosis variant bovis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT236704 WP_000388479.1 NZ_CP092581:2700751-2701020 [Staphylococcus aureus]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT236704 NZ_LR699570:c1939137-1938910 [Mycobacterium tuberculosis variant bovis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |