Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2473128..2473651 Replicon chromosome
Accession NZ_CP092581
Organism Staphylococcus aureus strain VRMSSA-WC111

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag MKI52_RS12370 Protein ID WP_000074049.1
Coordinates 2473128..2473394 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MKI52_RS12375 Protein ID WP_000587616.1
Coordinates 2473394..2473651 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI52_RS12350 (MKI52_002445) 2468435..2469622 - 1188 WP_000026189.1 MFS transporter -
MKI52_RS12355 (MKI52_002446) 2470018..2470794 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
MKI52_RS12360 (MKI52_002447) 2470787..2471449 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
MKI52_RS12365 (MKI52_002448) 2471697..2472773 - 1077 WP_001076673.1 M42 family metallopeptidase -
MKI52_RS12370 (MKI52_002449) 2473128..2473394 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
MKI52_RS12375 (MKI52_002450) 2473394..2473651 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI52_RS12380 (MKI52_002451) 2474010..2474465 + 456 WP_000732076.1 DUF1307 domain-containing protein -
MKI52_RS12385 (MKI52_002452) 2474633..2476198 - 1566 WP_000143492.1 FMN-binding glutamate synthase family protein -
MKI52_RS12390 (MKI52_002453) 2476393..2477142 + 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T236703 WP_000074049.1 NZ_CP092581:c2473394-2473128 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T236703 NZ_LR699570:1755143-1755547 [Mycobacterium tuberculosis variant bovis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT236703 WP_000587616.1 NZ_CP092581:c2473651-2473394 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT236703 NZ_LR699570:1754934-1755137 [Mycobacterium tuberculosis variant bovis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References