Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1936643..1937440 | Replicon | chromosome |
| Accession | NZ_CP092581 | ||
| Organism | Staphylococcus aureus strain VRMSSA-WC111 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MKI52_RS09555 | Protein ID | WP_000525008.1 |
| Coordinates | 1936979..1937440 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | MKI52_RS09550 | Protein ID | WP_001260487.1 |
| Coordinates | 1936643..1936966 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI52_RS09485 (MKI52_001881) | 1931960..1932493 | - | 534 | WP_001004326.1 | host-nuclease inhibitor Gam family protein | - |
| MKI52_RS09490 (MKI52_001882) | 1932486..1932737 | - | 252 | WP_000683290.1 | hypothetical protein | - |
| MKI52_RS09495 (MKI52_001883) | 1932747..1933007 | - | 261 | WP_000291481.1 | DUF1108 family protein | - |
| MKI52_RS09500 (MKI52_001884) | 1933012..1933314 | - | 303 | WP_000163430.1 | DUF2482 family protein | - |
| MKI52_RS09505 (MKI52_001885) | 1933407..1933568 | - | 162 | WP_000048124.1 | DUF1270 family protein | - |
| MKI52_RS09510 (MKI52_001886) | 1933561..1933776 | - | 216 | WP_000977384.1 | hypothetical protein | - |
| MKI52_RS09515 (MKI52_001887) | 1933790..1934239 | - | 450 | WP_000993183.1 | hypothetical protein | - |
| MKI52_RS09520 (MKI52_001888) | 1934279..1934503 | - | 225 | WP_000187184.1 | hypothetical protein | - |
| MKI52_RS09525 (MKI52_001889) | 1934504..1935295 | - | 792 | WP_001157019.1 | phage antirepressor KilAC domain-containing protein | - |
| MKI52_RS09530 (MKI52_001890) | 1935352..1935591 | + | 240 | WP_000438628.1 | hypothetical protein | - |
| MKI52_RS09535 (MKI52_001891) | 1935581..1935760 | - | 180 | WP_000393082.1 | hypothetical protein | - |
| MKI52_RS09540 (MKI52_001892) | 1935775..1936218 | - | 444 | WP_000435356.1 | hypothetical protein | - |
| MKI52_RS09545 (MKI52_001893) | 1936231..1936479 | - | 249 | WP_000272859.1 | helix-turn-helix transcriptional regulator | - |
| MKI52_RS09550 (MKI52_001894) | 1936643..1936966 | + | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MKI52_RS09555 (MKI52_001895) | 1936979..1937440 | + | 462 | WP_000525008.1 | hypothetical protein | Toxin |
| MKI52_RS09560 (MKI52_001896) | 1937624..1938145 | + | 522 | WP_001102444.1 | hypothetical protein | - |
| MKI52_RS09565 (MKI52_001897) | 1938138..1938608 | + | 471 | WP_000183249.1 | hypothetical protein | - |
| MKI52_RS09570 (MKI52_001898) | 1938678..1939724 | + | 1047 | WP_001145732.1 | tyrosine-type recombinase/integrase | - |
| MKI52_RS09575 (MKI52_001899) | 1939769..1940914 | + | 1146 | WP_001245449.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| MKI52_RS09580 (MKI52_001900) | 1941174..1941704 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1895271..1939724 | 44453 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18034.35 Da Isoelectric Point: 4.6899
>T236697 WP_000525008.1 NZ_CP092581:1936979-1937440 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T236697 NZ_LR699570:1240105-1240479 [Mycobacterium tuberculosis variant bovis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT236697 WP_001260487.1 NZ_CP092581:1936643-1936966 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT236697 NZ_LR699570:1239911-1240108 [Mycobacterium tuberculosis variant bovis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|