Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 826105..826582 | Replicon | chromosome |
| Accession | NZ_CP092581 | ||
| Organism | Staphylococcus aureus strain VRMSSA-WC111 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | MKI52_RS03955 | Protein ID | WP_000052076.1 |
| Coordinates | 826105..826293 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | MKI52_RS03960 | Protein ID | WP_001059690.1 |
| Coordinates | 826322..826582 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI52_RS03925 (MKI52_000777) | 822099..822620 | + | 522 | WP_000824482.1 | hypothetical protein | - |
| MKI52_RS03930 (MKI52_000778) | 822961..823647 | + | 687 | WP_000141557.1 | thermonuclease family protein | - |
| MKI52_RS03935 (MKI52_000779) | 824004..824204 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| MKI52_RS03940 (MKI52_000780) | 824696..824914 | - | 219 | WP_000005886.1 | hypothetical protein | - |
| MKI52_RS03945 (MKI52_000781) | 824976..825260 | - | 285 | WP_001004399.1 | hypothetical protein | - |
| MKI52_RS03950 (MKI52_000782) | 825348..825917 | - | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
| MKI52_RS03955 (MKI52_000783) | 826105..826293 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| MKI52_RS03960 (MKI52_000784) | 826322..826582 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| MKI52_RS03965 (MKI52_000785) | 826923..827126 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| MKI52_RS03970 (MKI52_000786) | 827123..827359 | - | 237 | WP_000349581.1 | hypothetical protein | - |
| MKI52_RS03975 (MKI52_000787) | 827584..828165 | + | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
| MKI52_RS03980 (MKI52_000788) | 828238..828855 | - | 618 | WP_000255551.1 | LysE/ArgO family amino acid transporter | - |
| MKI52_RS03985 (MKI52_000789) | 829010..829504 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| MKI52_RS03990 (MKI52_000790) | 829903..830325 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| MKI52_RS03995 (MKI52_000791) | 830473..831189 | + | 717 | WP_000150011.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp | 792432..829504 | 37072 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T236693 WP_000052076.1 NZ_CP092581:c826293-826105 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T236693 NZ_LR699570:842218-842646 [Mycobacterium tuberculosis variant bovis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT236693 WP_001059690.1 NZ_CP092581:c826582-826322 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT236693 NZ_LR699570:841937-842194 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |