Detailed information of TA system TA023669

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelB(antitoxin)
• Location: 1991964..1992579
• Replicon: chromosome
• Accession: NC_012471
• Organism: Streptococcus equi subsp. equi 4047

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C0M8Y9
• Locus tag: SEQ_RS09720
• Protein ID: WP_012680125.1
• Coordinates: 1991964..1992302 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C0M8Z0
• Locus tag: SEQ_RS09725
• Protein ID: WP_012680126.1
• Coordinates: 1992292..1992579 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEQ_RS09700	1988023..1989033	+	1011	WP_012680123.1	UDP-glucose 4-epimerase GalE	-
SEQ_RS09705	1989110..1990153	+	1044	WP_012680124.1	galactose mutarotase	-
SEQ_RS11410	1990454..1990597	+	144	WP_079994102.1	transposase	-
SEQ_RS11415	1991211..1991372	+	162	WP_074632276.1	transposase	-
SEQ_RS09720	1991964..1992302	-	339	WP_012680125.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SEQ_RS09725	1992292..1992579	-	288	WP_012680126.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SEQ_RS09730	1992941..1994392	-	1452	WP_012680127.1	putative DNA binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-100)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (11-91)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 13203.98 Da
• Isoelectric Point: 4.6787

>T23669 WP_012680125.1 NC_012471:c1992302-1991964 [Streptococcus equi subsp. equi 4047]
MAYDIYISNKAEQDLDEIYNYYLTEFSHSSAQKVIESLQSAISILEISPEGYVDFDDRVGRKLFPEGQLRMIPSKHFIVF
YLIRQSRVDILRIRSTKTDYLNDLENLFNNIL

Nucleotide

• Length: 339 bp

>T23669 NC_012471:c1992302-1991964 [Streptococcus equi subsp. equi 4047]
ATGGCTTATGATATCTATATTTCAAATAAGGCAGAACAAGATTTAGATGAAATCTATAACTACTATTTAACAGAATTTTC
GCACTCAAGCGCTCAAAAAGTTATTGAATCTTTGCAGTCAGCTATTTCTATTCTTGAGATATCCCCTGAAGGTTATGTTG
ATTTTGACGATCGTGTAGGACGTAAACTATTTCCTGAAGGCCAGCTAAGGATGATTCCTAGTAAGCATTTCATAGTATTT
TATTTAATTCGTCAGTCAAGGGTAGATATTCTTCGTATTAGAAGTACTAAAACTGATTATTTAAATGATTTAGAGAATCT
TTTTAACAATATCCTTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10977.52 Da
• Isoelectric Point: 4.4777

>AT23669 WP_012680126.1 NC_012471:c1992579-1992292 [Streptococcus equi subsp. equi 4047]
MATLIRDRQYNFRVNTEMMEEAKRILEAKNISVPDALNLFVERVVEEKDLPIKTAEQIRAESFLNELISELDEGYQDILA
GRTKPANEVFSKYGL

Nucleotide

• Length: 288 bp

>AT23669 NC_012471:c1992579-1992292 [Streptococcus equi subsp. equi 4047]
ATGGCTACATTAATAAGAGATAGACAGTATAATTTTAGAGTAAATACGGAAATGATGGAAGAAGCAAAGCGTATTTTAGA
AGCTAAAAATATTAGTGTTCCAGATGCTCTTAATCTATTTGTTGAACGGGTGGTGGAAGAAAAAGATTTACCTATTAAAA
CTGCAGAACAAATTAGAGCTGAATCATTTTTAAATGAACTGATATCAGAGCTTGATGAAGGGTATCAAGATATTTTAGCA
GGACGTACGAAGCCAGCTAATGAGGTATTTTCAAAATATGGCTTATGA

Structures

Toxin

• AlphaFold DB: C0M8Y9

Antitoxin

• AlphaFold DB: C0M8Z0