Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 83596..84115 Replicon plasmid unnamed1
Accession NZ_CP092577
Organism Enterococcus faecalis strain VRE-WC031

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag MKI49_RS15375 Protein ID WP_000588503.1
Coordinates 83858..84115 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag MKI49_RS15370 Protein ID WP_000388479.1
Coordinates 83596..83865 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI49_RS15335 (MKI49_003054) 79167..79583 - 417 WP_001232859.1 hypothetical protein -
MKI49_RS15340 (MKI49_003055) 79586..79870 - 285 WP_000353844.1 hypothetical protein -
MKI49_RS15345 (MKI49_003056) 80236..80460 + 225 WP_000410576.1 hypothetical protein -
MKI49_RS15350 (MKI49_003058) 81583..82263 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
MKI49_RS15355 (MKI49_003059) 82339..82905 + 567 Protein_94 hypothetical protein -
MKI49_RS15360 83070..83270 + 201 WP_001033544.1 4-hydroxybenzoate octaprenyltransferase -
MKI49_RS15365 (MKI49_003060) 83286..83465 + 180 WP_001120991.1 hypothetical protein -
MKI49_RS15370 (MKI49_003061) 83596..83865 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI49_RS15375 (MKI49_003062) 83858..84115 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
MKI49_RS15380 84756..85139 + 384 WP_242427989.1 hypothetical protein -
MKI49_RS15385 85345..85578 + 234 WP_242427992.1 hypothetical protein -
MKI49_RS15390 (MKI49_003064) 85743..86357 - 615 WP_001261742.1 recombinase family protein -
MKI49_RS15395 (MKI49_003065) 86807..88132 + 1326 WP_000969590.1 Y-family DNA polymerase -
MKI49_RS15400 (MKI49_003066) 88125..88475 + 351 WP_000568378.1 hypothetical protein -
MKI49_RS15405 (MKI49_003067) 88472..88651 + 180 WP_001021554.1 hypothetical protein -
MKI49_RS15410 (MKI49_003068) 88787..89077 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') / VanHAX groEL 1..90885 90885


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T236688 WP_000588503.1 NZ_CP092577:83858-84115 [Enterococcus faecalis]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T236688 NZ_LR699570:718330-718737 [Mycobacterium tuberculosis variant bovis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT236688 WP_000388479.1 NZ_CP092577:83596-83865 [Enterococcus faecalis]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT236688 NZ_LR699570:718073-718333 [Mycobacterium tuberculosis variant bovis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References