Detailed information of TA system TA023668

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1252990..1254418
• Replicon: chromosome
• Accession: NC_012471
• Organism: Streptococcus equi subsp. equi 4047

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: B6YPW2
• Locus tag: SEQ_RS06110
• Protein ID: WP_012679622.1
• Coordinates: 1252990..1253832 (-)
• Length: 281 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: B6YPW1
• Locus tag: SEQ_RS06115
• Protein ID: WP_012679623.1
• Coordinates: 1253825..1254418 (-)
• Length: 198 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEQ_RS06095	1249763..1250509	-	747	WP_012679619.1	hypothetical protein	-
SEQ_RS06100	1250551..1251102	-	552	WP_012679620.1	hypothetical protein	-
SEQ_RS06105	1251106..1252818	-	1713	WP_012679621.1	DNA topoisomerase 3	-
SEQ_RS06110	1252990..1253832	-	843	WP_012679622.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
SEQ_RS06115	1253825..1254418	-	594	WP_012679623.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
SEQ_RS06120	1254671..1256107	-	1437	WP_142240632.1	DUF4366 domain-containing protein	-
SEQ_RS06125	1256112..1256399	-	288	WP_012679625.1	conjugal transfer protein	-
SEQ_RS06130	1256412..1258700	-	2289	WP_012679626.1	CHAP domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1207299..1271960	64661

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-268)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-51)

Sequences

Toxin

Protein

• Length: 281 a.a.
• Molecular weight: 32683.90 Da
• Isoelectric Point: 5.9694

>T23668 WP_012679622.1 NC_012471:c1253832-1252990 [Streptococcus equi subsp. equi 4047]
MNKAKLTALCHKVSKEVGLSFNAVMLYYFLESILKKLAGSKYSERFIFKGGFLLSSVVGIDSRSTVDIDFLLRNMQLSEE
NIVQMLNETLKPEEFDDIFYELQNIVPIKEEDQYGGFRANILCKMENIRQIVPLDIATGDVITPHPIDYKYVSSFGEEEI
IIKAYPIETMLAEKIQTIYARGFLNSRSKDYYDLYIIYKLKDKDVNVEILREACRKTFSYRKTEFDIGKIIDLLEKLKIN
EAFLKRWQAYSRKNLYAKDITFEEVLDNGIKMVEKIKNEN

Nucleotide

• Length: 843 bp

>T23668 NC_012471:c1253832-1252990 [Streptococcus equi subsp. equi 4047]
ATGAATAAAGCTAAATTAACGGCTCTTTGCCATAAAGTTAGTAAAGAAGTCGGTCTTTCGTTTAATGCTGTTATGTTATA
TTATTTTTTAGAAAGTATTTTAAAAAAATTAGCAGGAAGCAAATATAGTGAACGATTTATTTTTAAGGGCGGCTTTTTGT
TATCAAGTGTAGTTGGAATTGATTCAAGAAGTACTGTAGATATAGACTTTCTTTTGAGAAATATGCAACTATCAGAAGAA
AATATTGTTCAAATGCTGAACGAAACTTTAAAACCGGAAGAATTCGACGATATTTTTTATGAATTGCAAAACATTGTGCC
AATCAAAGAAGAAGATCAATATGGAGGATTTCGTGCAAATATCTTATGTAAAATGGAAAATATAAGACAGATTGTACCAC
TTGACATTGCAACAGGAGATGTTATTACACCTCATCCGATAGATTATAAGTATGTGAGTTCTTTTGGAGAAGAAGAAATA
ATAATCAAGGCTTATCCGATAGAAACTATGCTTGCAGAAAAAATACAAACTATTTATGCAAGAGGATTTTTAAATAGTAG
AAGTAAGGATTATTACGATCTTTATATTATTTATAAATTAAAGGATAAAGATGTAAATGTAGAGATATTAAGAGAGGCTT
GCAGAAAAACTTTTAGTTATAGAAAAACAGAATTTGACATAGGTAAAATCATAGACTTACTGGAAAAATTGAAAATAAAT
GAAGCCTTTTTGAAAAGATGGCAAGCTTATTCAAGAAAAAATCTGTATGCGAAAGATATAACTTTTGAAGAAGTATTGGA
CAACGGAATAAAAATGGTGGAAAAAATAAAGAATGAAAATTAG

Antitoxin

Protein

• Length: 198 a.a.
• Molecular weight: 23345.76 Da
• Isoelectric Point: 8.6522

>AT23668 WP_012679623.1 NC_012471:c1254418-1253825 [Streptococcus equi subsp. equi 4047]
MNYENKIEKYLKQSGGIITTAYCKENNIPTIYLSRLLKDGRLSKVRKGIYITKDGDYDEYYFFQHQYKKAIFSYETALYL
LGQTDKIPWSIDVTVYNGYKFNEKPNGFNVHYVKKSIYDLGVTQKPTMFGNKVKVYSYERTLCDFIAHKEEMDIEVYVKL
IQSYSSYKERDIHSLYDIAMKMGIENKVREVMEVAYE

Nucleotide

• Length: 594 bp

>AT23668 NC_012471:c1254418-1253825 [Streptococcus equi subsp. equi 4047]
ATGAATTATGAAAATAAAATTGAAAAATATTTGAAGCAATCAGGTGGAATTATTACAACAGCATACTGTAAGGAAAATAA
TATACCGACGATATATCTCAGTCGACTATTGAAAGATGGGAGATTGTCAAAAGTAAGAAAAGGAATTTATATAACGAAAG
ATGGGGATTACGATGAGTATTATTTCTTTCAACATCAGTATAAAAAGGCGATATTTTCTTATGAAACAGCACTTTACCTG
CTTGGACAAACAGATAAAATTCCTTGGAGTATCGATGTAACCGTTTATAACGGATATAAATTTAATGAAAAACCGAACGG
TTTCAATGTTCATTATGTAAAAAAATCAATTTATGACTTAGGGGTAACCCAAAAACCTACAATGTTTGGAAATAAAGTTA
AGGTATATTCATATGAGAGGACACTCTGTGATTTTATTGCTCATAAAGAAGAAATGGATATAGAGGTTTATGTAAAACTT
ATTCAATCATATTCCTCTTATAAAGAAAGAGATATCCATTCCCTCTATGACATTGCAATGAAAATGGGAATTGAAAATAA
AGTAAGAGAGGTTATGGAGGTGGCTTATGAATAA

Structures

Toxin

• AlphaFold DB: B6YPW2

Antitoxin

• AlphaFold DB: B6YPW1