Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 874347..874830 Replicon chromosome
Accession NC_012471
Organism Streptococcus equi subsp. equi 4047

Toxin (Protein)


Gene name relE Uniprot ID C0M6K7
Locus tag SEQ_RS04405 Protein ID WP_012679379.1
Coordinates 874570..874830 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4U2B9
Locus tag SEQ_RS04400 Protein ID WP_012515410.1
Coordinates 874347..874568 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SEQ_RS04380 871307..871588 + 282 WP_012679377.1 hypothetical protein -
SEQ_RS04385 871773..872228 - 456 WP_012679378.1 DUF1694 domain-containing protein -
SEQ_RS04390 872459..873766 + 1308 WP_012515409.1 phosphopyruvate hydratase -
SEQ_RS04395 873902..874138 - 237 Protein_824 transposase -
SEQ_RS11675 874121..874267 + 147 WP_162009866.1 hypothetical protein -
SEQ_RS04400 874347..874568 + 222 WP_012515410.1 hypothetical protein Antitoxin
SEQ_RS04405 874570..874830 + 261 WP_012679379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SEQ_RS04410 875483..876088 + 606 WP_012679381.1 HAD family hydrolase -
SEQ_RS04415 876556..879336 + 2781 WP_012679382.1 endonuclease/exonuclease/phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10291.85 Da        Isoelectric Point: 9.8245

>T23667 WP_012679379.1 NC_012471:874570-874830 [Streptococcus equi subsp. equi 4047]
MYRIEYSKKAQKQIKKVDKQIQRLLFAWIDKYLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKMVVLALEFG
HRKDIY

Download         Length: 261 bp

>T23667 NC_012471:874570-874830 [Streptococcus equi subsp. equi 4047]
ATGTACCGTATAGAGTATTCTAAAAAGGCTCAAAAGCAGATTAAGAAAGTAGATAAGCAAATTCAGAGGTTGCTATTTGC
TTGGATTGATAAGTATTTAGAGGGAACAGATAACCCACGCGCAAATGGCAAAGGTTTGACCGGAAATCATGCTAATGAGT
GGCGTTATCGTATTGGTGATTATAGGCTTATTTGTGATATTCAAGATGATAAGATGGTTGTTTTAGCGCTTGAGTTTGGG
CATCGTAAAGATATTTACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8536.57 Da        Isoelectric Point: 4.6104

>AT23667 WP_012515410.1 NC_012471:874347-874568 [Streptococcus equi subsp. equi 4047]
MSTVTIRLNQEEEIFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYAEYKADPETISHADFKKELGL

Download         Length: 222 bp

>AT23667 NC_012471:874347-874568 [Streptococcus equi subsp. equi 4047]
ATGAGTACAGTTACTATCAGATTAAATCAAGAAGAAGAAATATTTTTCAAAAGTTACGCCCAACTCACAGGGCAAAGTTT
ATCAAGTCTATTTAAAAAAGCCCTTGAGCGGGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCCTATGCTG
AATATAAAGCAGACCCTGAGACAATTAGCCATGCTGATTTTAAGAAAGAGCTAGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C0M6K7

Antitoxin

Source ID Structure
AlphaFold DB A0A380KCN4

References