Detailed information of TA system TA023666

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1316706..1317189
• Replicon: chromosome
• Accession: NC_012470
• Organism: Streptococcus equi subsp. zooepidemicus

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SZO_RS06175
• Protein ID: WP_012678124.1
• Coordinates: 1316706..1316966 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A922NW74
• Locus tag: SZO_RS06180
• Protein ID: WP_012678125.1
• Coordinates: 1316968..1317189 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SZO_RS06165	1311744..1314524	-	2781	WP_012678122.1	endonuclease/exonuclease/phosphatase family protein	-
SZO_RS06170	1314990..1315595	-	606	WP_012678123.1	HAD family hydrolase	-
SZO_RS06175	1316706..1316966	-	261	WP_012678124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SZO_RS06180	1316968..1317189	-	222	WP_012678125.1	hypothetical protein	Antitoxin
SZO_RS10500	1317399..1317635	+	237	Protein_1174	transposase	-
SZO_RS10505	1317882..1317971	-	90	WP_111677961.1	type I toxin-antitoxin system Fst family toxin	-
SZO_RS06190	1318210..1319517	-	1308	WP_012515409.1	phosphopyruvate hydratase	-
SZO_RS06195	1319749..1320204	+	456	WP_012678126.1	DUF1694 domain-containing protein	-
SZO_RS06200	1320387..1320650	-	264	WP_012678127.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10244.76 Da
• Isoelectric Point: 9.6925

>T23666 WP_012678124.1 NC_012470:c1316966-1316706 [Streptococcus equi subsp. zooepidemicus]
MYHIEYSKKAQKQIKKLDKQIQRLLFAWIDKHLEGTDNPRANGKGVAGNHANEWRYRIGDYRLICDIQDDKMVILALEFG
HRRDVY

Nucleotide

• Length: 261 bp

>T23666 NC_012470:c1316966-1316706 [Streptococcus equi subsp. zooepidemicus]
ATGTATCATATAGAGTATTCTAAAAAGGCTCAAAAGCAGATTAAGAAACTAGATAAGCAAATTCAGAGGTTGCTATTTGC
TTGGATTGATAAGCATTTAGAGGGAACAGATAACCCACGCGCAAATGGTAAGGGTGTGGCAGGAAATCATGCTAATGAAT
GGCGTTATCGTATTGGTGATTATCGGCTTATTTGTGATATTCAAGATGATAAGATGGTTATTTTAGCGCTTGAGTTTGGG
CATAGGCGAGATGTTTATTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8506.54 Da
• Isoelectric Point: 4.6104

>AT23666 WP_012678125.1 NC_012470:c1317189-1316968 [Streptococcus equi subsp. zooepidemicus]
MGTVTIRLNQEEEIFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKLYHQAYAEYKADPETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT23666 NC_012470:c1317189-1316968 [Streptococcus equi subsp. zooepidemicus]
ATGGGTACAGTTACTATCAGATTAAATCAAGAGGAAGAAATATTTTTCAAAAGTTACGCCCAACTCACAGGGCAAAGTTT
ATCAAGTCTATTTAAAAAAGCCCTTGAGCGGGATATTGAAGATGAGTATGATTTAAAACTCTATCATCAAGCCTATGCTG
AATATAAAGCAGACCCTGAGACAATTAGCCATGCGGATTTTAAGAAAGAGCTAGGCTTATAA