Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 2639953..2640651 | Replicon | chromosome |
| Accession | NZ_CP092574 | ||
| Organism | Enterococcus faecalis strain VSE-WC032 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | A0A059N529 |
| Locus tag | MKI56_RS13300 | Protein ID | WP_002373917.1 |
| Coordinates | 2640307..2640651 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | MKI56_RS13295 | Protein ID | WP_010782967.1 |
| Coordinates | 2639953..2640288 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI56_RS13245 (2635473) | 2635473..2636288 | - | 816 | WP_010773519.1 | PD-(D/E)XK nuclease-like domain-containing protein | - |
| MKI56_RS13250 (2636251) | 2636251..2637267 | - | 1017 | WP_002393794.1 | RecT family recombinase | - |
| MKI56_RS13255 (2637370) | 2637370..2637594 | - | 225 | WP_002370012.1 | hypothetical protein | - |
| MKI56_RS13260 (2637591) | 2637591..2637890 | - | 300 | WP_010773520.1 | hypothetical protein | - |
| MKI56_RS13265 (2637977) | 2637977..2638393 | - | 417 | WP_002417286.1 | hypothetical protein | - |
| MKI56_RS13270 (2638394) | 2638394..2638564 | - | 171 | WP_010706857.1 | hypothetical protein | - |
| MKI56_RS13275 (2638599) | 2638599..2638868 | - | 270 | WP_002365131.1 | hypothetical protein | - |
| MKI56_RS13280 (2638886) | 2638886..2639095 | - | 210 | WP_010706858.1 | DUF2829 domain-containing protein | - |
| MKI56_RS13285 (2639128) | 2639128..2639466 | - | 339 | WP_010706859.1 | hypothetical protein | - |
| MKI56_RS13290 (2639479) | 2639479..2639661 | - | 183 | WP_002358110.1 | hypothetical protein | - |
| MKI56_RS13295 (2639953) | 2639953..2640288 | + | 336 | WP_010782967.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MKI56_RS13300 (2640307) | 2640307..2640651 | + | 345 | WP_002373917.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| MKI56_RS13305 (2640676) | 2640676..2640909 | - | 234 | WP_002367290.1 | hypothetical protein | - |
| MKI56_RS13310 (2640921) | 2640921..2641682 | + | 762 | WP_002367291.1 | hypothetical protein | - |
| MKI56_RS13315 (2641858) | 2641858..2642688 | + | 831 | Protein_2609 | site-specific integrase | - |
| MKI56_RS15500 (2642784) | 2642784..2643038 | + | 255 | WP_277956769.1 | tyrosine-type recombinase/integrase | - |
| MKI56_RS13320 (2643141) | 2643141..2643290 | - | 150 | WP_002356321.1 | 50S ribosomal protein L33 | - |
| MKI56_RS13325 (2643416) | 2643416..2645554 | - | 2139 | WP_024041710.1 | penicillin-binding transpeptidase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2599954..2642922 | 42968 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13594.61 Da Isoelectric Point: 5.6177
>T236650 WP_002373917.1 NZ_CP092574:2640307-2640651 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK
Download Length: 345 bp
>T236650 NZ_LR699014:c354329-353949 [Citrobacter werkmanii]
ATGCAAACCTTATCCGCCATCCCGAAGCGGAAGGCACCGTCACGCCCGACGCCCGTTGAAATCTGGCAGCAACTTCTTAC
GTATCTGTTAAAAAGACATTACGGCCTTTCGCTTAGCGACACGCAATTTTCCGATGAGGAGATTATTACGCAATATATTG
ACGCCGGTATCTCACTGTCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTGCGGATTGATCGTCCCGGTTTC
TCCATTAAGCATCAGTCCCCTTTTATCGGGGTGATTGATATTCTCCGGGCCAGACGGGCAACGGGTTTGATGCAACGTAA
CGGGTATAAAAGGATCACTCTTCTCATCGCTGGAAATGCAGCTCAGGAGCAACATTCATGA
ATGCAAACCTTATCCGCCATCCCGAAGCGGAAGGCACCGTCACGCCCGACGCCCGTTGAAATCTGGCAGCAACTTCTTAC
GTATCTGTTAAAAAGACATTACGGCCTTTCGCTTAGCGACACGCAATTTTCCGATGAGGAGATTATTACGCAATATATTG
ACGCCGGTATCTCACTGTCAGATGCACTCAATTTTCTCGTTGAAAAATCTGAACTGGTGCGGATTGATCGTCCCGGTTTC
TCCATTAAGCATCAGTCCCCTTTTATCGGGGTGATTGATATTCTCCGGGCCAGACGGGCAACGGGTTTGATGCAACGTAA
CGGGTATAAAAGGATCACTCTTCTCATCGCTGGAAATGCAGCTCAGGAGCAACATTCATGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12828.40 Da Isoelectric Point: 4.8074
>AT236650 WP_010782967.1 NZ_CP092574:2639953-2640288 [Enterococcus faecalis]
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFNVSVDYLLGRTDNTKATDEKNSDDLDD
VLDNVMSFDGEPLDDHDREVIRAYLKGRFGK
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFNVSVDYLLGRTDNTKATDEKNSDDLDD
VLDNVMSFDGEPLDDHDREVIRAYLKGRFGK
Download Length: 336 bp
>AT236650 NZ_LR699014:c354752-354387 [Citrobacter werkmanii]
TTGTCGAATCCAATACCTCCAGTAAACCATGATGTCTCTGAGCCCTGGTGGGGGCTGAAACCGGGCATCACTCCGTGTTT
TGGCGCACGACTGGTACAGGAAGGCAACCGCCTGCATTATCTGGCTGATCGGGCCAGTATCGCCGGTGTGTTCAGCGATG
CGGATTTACGCCATCTCGATCAAGCATTTCCGGTACTGCTCAAACAGCTGGAATTAATGCTGGTTTCCGGTGAGCTCAAT
CCCTGCCATCAGCACTGTGTCACGTTATATGCAAAAGGGCTGACCTGTGAAGCAGATTCCCTCGGATCACATGGCTACAT
TTATACAGCAATTTATCCGACACCAGACGACAGCATAACCCGGTAA
TTGTCGAATCCAATACCTCCAGTAAACCATGATGTCTCTGAGCCCTGGTGGGGGCTGAAACCGGGCATCACTCCGTGTTT
TGGCGCACGACTGGTACAGGAAGGCAACCGCCTGCATTATCTGGCTGATCGGGCCAGTATCGCCGGTGTGTTCAGCGATG
CGGATTTACGCCATCTCGATCAAGCATTTCCGGTACTGCTCAAACAGCTGGAATTAATGCTGGTTTCCGGTGAGCTCAAT
CCCTGCCATCAGCACTGTGTCACGTTATATGCAAAAGGGCTGACCTGTGAAGCAGATTCCCTCGGATCACATGGCTACAT
TTATACAGCAATTTATCCGACACCAGACGACAGCATAACCCGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|