Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907(toxin) |
Location | 1642106..1642677 | Replicon | chromosome |
Accession | NZ_CP092574 | ||
Organism | Enterococcus faecalis strain VSE-WC032 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | R3HR30 |
Locus tag | MKI56_RS08285 | Protein ID | WP_001278770.1 |
Coordinates | 1642336..1642677 (+) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A6B1XRC3 |
Locus tag | MKI56_RS08280 | Protein ID | WP_000958277.1 |
Coordinates | 1642106..1642336 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MKI56_RS08250 (1637374) | 1637374..1637976 | - | 603 | WP_001062586.1 | recombinase family protein | - |
MKI56_RS08255 (1637990) | 1637990..1638160 | - | 171 | WP_000713595.1 | hypothetical protein | - |
MKI56_RS08260 (1638483) | 1638483..1639163 | + | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
MKI56_RS08265 (1639291) | 1639291..1640250 | + | 960 | WP_000222577.1 | IS30-like element IS1252 family transposase | - |
MKI56_RS08270 (1640683) | 1640683..1641255 | - | 573 | WP_000170424.1 | recombinase family protein | - |
MKI56_RS08275 (1641271) | 1641271..1641876 | - | 606 | WP_000599739.1 | Fic family protein | - |
MKI56_RS08280 (1642106) | 1642106..1642336 | + | 231 | WP_000958277.1 | hypothetical protein | Antitoxin |
MKI56_RS08285 (1642336) | 1642336..1642677 | + | 342 | WP_001278770.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
MKI56_RS08290 (1642790) | 1642790..1643731 | + | 942 | WP_242427379.1 | hypothetical protein | - |
MKI56_RS08295 (1643978) | 1643978..1644580 | + | 603 | WP_242427380.1 | Fic family protein | - |
MKI56_RS08300 (1645293) | 1645293..1645558 | + | 266 | Protein_1611 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
MKI56_RS08305 (1645551) | 1645551..1645826 | + | 276 | WP_000889655.1 | type II toxin-antitoxin system YafQ family toxin | - |
MKI56_RS08310 (1646737) | 1646737..1646997 | - | 261 | WP_242427381.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | erm(B) / aph(3')-III / ant(6)-Ia | cylI / cylA / cylA / cylB / cylB / cylB / cylM / cylM / cylM / cylM / cylM / cylS / cylL / cylR1 / hasC / sprE / gelE / fsrC / fss3 | 1578709..1961335 | 382626 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13220.44 Da Isoelectric Point: 8.8595
>T236648 WP_001278770.1 NZ_CP092574:1642336-1642677 [Enterococcus faecalis]
MSDEKKYIPKKGDIVWIDFDPSAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNMPTRYTLPDEMETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF
MSDEKKYIPKKGDIVWIDFDPSAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNMPTRYTLPDEMETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF
Download Length: 342 bp
>T236648 NZ_LR699011:3318395-3318685 [Roseburia hominis]
ATGAGGAAAACAAAGTACACCGTCAAGTACACGACCGCTTTCAAAAAGGACTACAAGCGGGCAATCAAGCGCGGCCTGAA
AATCGAATTGCTGGAACAGGTCGTGGCGCTGCTGTCGATGGGCGAACCGCTGCCGGATAAAAACCGCGATCACGATTTGT
CCGGCGATTGGGCAGGCCATCGAGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAAGAGGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA
ATGAGGAAAACAAAGTACACCGTCAAGTACACGACCGCTTTCAAAAAGGACTACAAGCGGGCAATCAAGCGCGGCCTGAA
AATCGAATTGCTGGAACAGGTCGTGGCGCTGCTGTCGATGGGCGAACCGCTGCCGGATAAAAACCGCGATCACGATTTGT
CCGGCGATTGGGCAGGCCATCGAGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAAGAGGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8536.45 Da Isoelectric Point: 4.2412
>AT236648 WP_000958277.1 NZ_CP092574:1642106-1642336 [Enterococcus faecalis]
MLTTKSRKQGSSVVLTLPSNNGQKPKADQEYIVMYSDDGTITLVPKLQDPFSGGSEGEYYEKDEWYDIEPGGRELF
MLTTKSRKQGSSVVLTLPSNNGQKPKADQEYIVMYSDDGTITLVPKLQDPFSGGSEGEYYEKDEWYDIEPGGRELF
Download Length: 231 bp
>AT236648 NZ_LR699011:3318120-3318398 [Roseburia hominis]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAGCT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAGGAAACGATTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGATAC
AATGACCTTGACGAGTTGTTTGCCGACCTGAAAAAATGA
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAGCT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAGGAAACGATTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGATAC
AATGACCTTGACGAGTTGTTTGCCGACCTGAAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | R3HR30 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6B1XRC3 |