Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1565912..1566587 Replicon chromosome
Accession NZ_CP092569
Organism Enterococcus faecium strain VRE-WC072

Toxin (Protein)


Gene name hicA Uniprot ID A0A430A2J6
Locus tag MKI62_RS07470 Protein ID WP_002350171.1
Coordinates 1566405..1566587 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A430A2G3
Locus tag MKI62_RS07465 Protein ID WP_042958047.1
Coordinates 1565912..1566367 (-) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI62_RS07455 (MKI62_001489) 1563722..1565305 - 1584 WP_002350174.1 DUF3991 domain-containing protein -
MKI62_RS07460 (MKI62_001490) 1565377..1565817 - 441 WP_002350173.1 hypothetical protein -
MKI62_RS07465 (MKI62_001491) 1565912..1566367 - 456 WP_042958047.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MKI62_RS07470 (MKI62_001492) 1566405..1566587 - 183 WP_002350171.1 type II toxin-antitoxin system HicA family toxin Toxin
MKI62_RS07475 (MKI62_001493) 1566657..1567898 - 1242 WP_002350170.1 MobP2 family relaxase -
MKI62_RS07480 (MKI62_001494) 1567901..1568449 - 549 WP_002350169.1 hypothetical protein -
MKI62_RS07485 (MKI62_001495) 1568449..1568706 - 258 WP_002350168.1 ribbon-helix-helix protein, CopG family -
MKI62_RS07490 (MKI62_001496) 1569069..1569884 - 816 WP_002350167.1 hypothetical protein -
MKI62_RS07495 (MKI62_001497) 1569906..1570196 - 291 WP_042958053.1 thioredoxin family protein -
MKI62_RS07500 (MKI62_001498) 1570337..1570951 - 615 WP_002350165.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(18-116)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6498.85 Da        Isoelectric Point: 11.3109

>T236641 WP_002350171.1 NZ_CP092569:c1566587-1566405 [Enterococcus faecium]
MPMTQNEMVKLLIEHGGVKVKGGKGSHIKVRFPGVNRPIIVPQKLPKGTENGILKQAGLK

Download         Length: 183 bp

>T236641 NZ_LR699009:4980720-4981082 [Pluralibacter gergoviae]
ATAACACAGAAATCTCTCTACTGGGTAGGTAGCAGCAGAAAGGATCTCCAGTCATTACCTGATGATGTGCAGGATGTATT
CGGCTATGCCCTGTATCTCGCTCAAACGGGCAGTAAACATTCTCAGAGCAAAGTGTTGAAAGGTTTTGGTAGCGCCGGAG
TGCTGGAGGTGGTTGAACAATTTTTCGGCAGCACCTATCGCGCTGTCTATACCGTAAAATTTGCCGATGCGGTCTATGTT
TTGCACGCATTTCAGAAGAAGTCCTCATCAGGGATCGCCACACCTAAATGCGATTTGAATAAGATTCATGAACGACTGAA
AGCCGCAGAGGATCATGCCAGGAGAGCGCACCATGAGCGATAA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16865.84 Da        Isoelectric Point: 4.0033

>AT236641 WP_042958047.1 NZ_CP092569:c1566367-1565912 [Enterococcus faecium]
MLVSYPALFYFENSEGYDPGFSVFFPDFPNTGGTSGSTISEALEMASDYLGILLSDDIEQERELPKPSLISSLSLEENDP
FKDDSDFNFEYDFEKSFVSMVSVDLSQYLGNNDPIKKTLTIPKWADKLGKDLHLNFSKTLTDAIVSKKMGA

Download         Length: 456 bp

>AT236641 NZ_LR699009:4981072-4981389 [Pluralibacter gergoviae]
ATGAGCGATAATATCGAAGTAAGCAGCGGTAACGTGTATACCGATCTGGGTGATAAATCTGCTGAAGAGATGCTGATCAA
AGCCCAGCTCGCTGCGGCTATCGGCCAAATCATTAAAAGTCGGGGCCTCACTCAGGAGCAGGCCGCAAAGCTGATTGGCC
TTACGCAACCAAAACTGTCAAACCTGCTGCGCGGTCAATTTCGCGGGATCAGCGAAGCAAAGATGCTGGAGTGTCTTACG
CGGCTGGGGCGCGATATCGAAATCGTGGTCAGCAAACCTCGCCAAACGCCGGGCAGTCTGAAAATAATCTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A430A2J6

Antitoxin

Source ID Structure
AlphaFold DB A0A430A2G3

References