Detailed information of TA system TA023664

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 949211..949709
• Replicon: chromosome
• Accession: NC_012469
• Organism: Streptococcus pneumoniae Taiwan19F-14

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SPT_RS04965
• Protein ID: WP_001812387.1
• Coordinates: 949455..949709 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: SPT_RS04960
• Protein ID: WP_000208080.1
• Coordinates: 949211..949453 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPT_RS04940	945033..946208	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
SPT_RS04945	946263..946967	+	705	WP_000722076.1	response regulator transcription factor	-
SPT_RS04950	946960..948309	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
SPT_RS04955	948311..949120	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
SPT_RS04960	949211..949453	+	243	WP_000208080.1	hypothetical protein	Antitoxin
SPT_RS04965	949455..949709	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPT_RS04970	949756..950529	+	774	WP_000731129.1	ion transporter	-
SPT_RS04975	950845..952191	-	1347	WP_001814919.1	IS1380-like element ISSpn5 family transposase	-
SPT_RS04980	952500..953486	-	987	WP_000204727.1	L-lactate dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	950845..952191	1346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T23664 WP_001812387.1 NC_012469:949455-949709 [Streptococcus pneumoniae Taiwan19F-14]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T23664 NC_012469:949455-949709 [Streptococcus pneumoniae Taiwan19F-14]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT23664 WP_000208080.1 NC_012469:949211-949453 [Streptococcus pneumoniae Taiwan19F-14]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT23664 NC_012469:949211-949453 [Streptococcus pneumoniae Taiwan19F-14]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7