Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 195111..195640 Replicon chromosome
Accession NZ_CP092569
Organism Enterococcus faecium strain VRE-WC072

Toxin (Protein)


Gene name relE Uniprot ID A0A828ZPW6
Locus tag MKI62_RS00965 Protein ID WP_002301121.1
Coordinates 195374..195640 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag MKI62_RS00960 Protein ID WP_002294199.1
Coordinates 195111..195374 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI62_RS00950 (MKI62_000189) 192486..194309 + 1824 WP_002294202.1 APC family permease -
MKI62_RS00955 (MKI62_000190) 194451..194636 - 186 WP_002348885.1 hypothetical protein -
MKI62_RS15250 194643..194771 + 129 WP_002294200.1 hypothetical protein -
MKI62_RS00960 (MKI62_000191) 195111..195374 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI62_RS00965 (MKI62_000192) 195374..195640 + 267 WP_002301121.1 Txe/YoeB family addiction module toxin Toxin
MKI62_RS00970 195841..196329 + 489 WP_002301120.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
MKI62_RS00975 (MKI62_000194) 196871..197542 - 672 WP_002301116.1 ABC transporter permease -
MKI62_RS00980 (MKI62_000195) 197539..198456 - 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
MKI62_RS00985 (MKI62_000196) 198453..199094 - 642 WP_002293405.1 ABC transporter permease -
MKI62_RS00990 (MKI62_000197) 199098..200273 - 1176 WP_002348889.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(M) / tet(L) lap 157942..336284 178342


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10619.04 Da        Isoelectric Point: 9.8346

>T236639 WP_002301121.1 NZ_CP092569:195374-195640 [Enterococcus faecium]
MSNYTVAIKNSATVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T236639 NZ_LR699009:4344177-4344530 [Pluralibacter gergoviae]
GTGTGGAACATTCAGGTAACAGAAACATACAAACTCTGGCATCAGGCGCTGAGCGCTAAAGACCAGGCACGGGTACTTGC
CATGCTCGACCTGCTGGAAAAGGAGGGTCCCCGGCTCGGCAGGCCGTATGCCGATACAATAAAAGGCTCCCGCTTCAGCA
ATATGAAAGAGCTCAGGATCCAGCGCCGGGGCGAGCCGCTGCGCATTTTTTACGTCTTCTCACCTGAACGCGAAGGCATC
CTGCTCTGTGCAGGCAACAAGTCAGGCGACGATAAGCGGTTTTATGACATCATGATCCCGCTCGCCGATGAAGAATACAC
TGAATATCTCAACCATTTTTATCAGTCGAGGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT236639 WP_002294199.1 NZ_CP092569:195111-195374 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT236639 NZ_LR699009:4344534-4344845 [Pluralibacter gergoviae]
ATGGTAACAACACTGAAGCAGCTGCGGGCGGAAACGACGCCGGAAGTGCTCGCCGAAGCCGACGCCCTCTATCAGGAGCT
GCTGCTGGAGTACAACCTGGCGAAGCTGCGTGAGATGGTCAATAAGACCCAGCAGGAGATGGCCGACAGTCTGGGCATTA
AGCAGCCGACGCTTGCCGGCATGGAGAAAAAGGGCAACGACATCAAGCTCTCTTCCCTCAAACGCTACGTAGAGGCGGCG
GGCTGCCGGCTGAATCTGGATATCGAGCTGCCGGACGGCACGCACTGCGCGTTTAAGCTTTCGGAACGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZPW6

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References