236638

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2540737..2541260 Replicon chromosome
Accession NZ_CP092567
Organism Staphylococcus aureus strain MRSA-WC000

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag MKI50_RS12805 Protein ID WP_000074049.1
Coordinates 2540737..2541003 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MKI50_RS12810 Protein ID WP_000587616.1
Coordinates 2541003..2541260 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI50_RS12785 (MKI50_002534) 2536044..2537231 - 1188 WP_000026189.1 MFS transporter -
MKI50_RS12790 (MKI50_002535) 2537627..2538403 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
MKI50_RS12795 (MKI50_002536) 2538396..2539058 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
MKI50_RS12800 (MKI50_002537) 2539306..2540382 - 1077 WP_001076673.1 M42 family metallopeptidase -
MKI50_RS12805 (MKI50_002538) 2540737..2541003 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
MKI50_RS12810 (MKI50_002539) 2541003..2541260 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI50_RS12815 (MKI50_002540) 2541619..2542074 + 456 WP_000732076.1 DUF1307 domain-containing protein -
MKI50_RS12820 (MKI50_002541) 2542242..2543807 - 1566 WP_000143492.1 FMN-binding glutamate synthase family protein -
MKI50_RS12825 (MKI50_002542) 2544002..2544751 + 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T236638 WP_000074049.1 NZ_CP092567:c2541003-2540737 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T236638 NZ_LR699009:c4270844-4270512 [Pluralibacter gergoviae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTAGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CGGCAGGTTTCACTGTTTCACTGGAAGAAGCGGGGACCAAAACAATGGGCGTTATTCGCTGCGACCAGCCCAGAACTATC
GATATCGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCGGACGCCGTTGTTAATGAGGTACTTGCCAGGCTGGATGC
GATTCTGAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT236638 WP_000587616.1 NZ_CP092567:c2541260-2541003 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT236638 NZ_LR699009:c4271102-4270845 [Pluralibacter gergoviae]
ATGTATACAACTCGCCTGAAAAAGGTTGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGCGCT
GACGACGGACAGCGAAGTCGGCATGACCATTAATAATGGTTGCCTGATAATCGAACCGCAGAAACGGCCTCATTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCATGCTGAAATGAGCGAAGAGGACCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References