236634

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2165481..2165995 Replicon chromosome
Accession NZ_CP092567
Organism Staphylococcus aureus strain MRSA-WC000

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MKI50_RS10860 Protein ID WP_000581792.1
Coordinates 2165481..2165690 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MKI50_RS10865 Protein ID WP_000138932.1
Coordinates 2165702..2165995 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI50_RS10840 (MKI50_002146) 2160989..2162347 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MKI50_RS10845 (MKI50_002147) 2162362..2163432 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MKI50_RS10850 (MKI50_002148) 2163750..2164952 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MKI50_RS10855 (MKI50_002149) 2165216..2165353 - 138 WP_000828354.1 Lmo0850 family protein -
MKI50_RS10860 (MKI50_002150) 2165481..2165690 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MKI50_RS10865 (MKI50_002151) 2165702..2165995 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MKI50_RS10870 (MKI50_002152) 2166161..2167654 + 1494 WP_000571554.1 cardiolipin synthase -
MKI50_RS10875 (MKI50_002153) 2167682..2168329 + 648 WP_001187633.1 HD domain-containing protein -
MKI50_RS10880 (MKI50_002154) 2169242..2170114 - 873 WP_000725802.1 membrane protein insertase YidC -
MKI50_RS10885 (MKI50_002155) 2170200..2170841 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T236634 WP_000581792.1 NZ_CP092567:c2165690-2165481 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T236634 NZ_LR699009:c2243285-2243067 [Pluralibacter gergoviae]
ATGTCAGATAAAGCTTTAACGAAAACGGATTATCTGATGCGTTTAAGGCGCTGTCAGAGTATTGATACGCTTGAACGCGT
CATCGAAAAAAATAAGTATGAACTTTCCGATAATGAACTGGCGGTTTTTTACTCAGCAGCCGATCACCGCCTTGCGGAGC
TGACGATGAATAAACTCTATGACAAGATCCCAACGTCGGTATGGAAATTTATACGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT236634 WP_000138932.1 NZ_CP092567:c2165995-2165702 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT236634 NZ_LR699009:c2243687-2243313 [Pluralibacter gergoviae]
ATGGACGAATATTCGCCAAAAAGACATGATCTCGCACAGCTTAAATTTCTCTGTGAAACCCTGTATCATGACTGCCTTGT
TAACCTTGAAGAGAACGGTGCAGGCTGGGTCAATGACCCTACGGCCGCAATCAACCTTCAACTTAACGAATTGATTGAAC
ACATTGCTACCTTCGCACTTAATTACAAAATTAAGTATAACGAAGACGATAAATTGATCGCACAAATTGATGAGTATCTG
GACGACACCTTTATGCTGTTCAGTAACTATGGCATTAATGCTGATGATTTACAGAAATGGCGAAAATCTGGAAACCGACT
TTTCCGCTGTTTCATAAACGCCAGCCGTGCTAATCCTGTTAGTCTCTCTTGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References