Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 2004349..2005146 | Replicon | chromosome |
| Accession | NZ_CP092567 | ||
| Organism | Staphylococcus aureus strain MRSA-WC000 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MKI50_RS10005 | Protein ID | WP_000525008.1 |
| Coordinates | 2004685..2005146 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | MKI50_RS10000 | Protein ID | WP_001260487.1 |
| Coordinates | 2004349..2004672 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI50_RS09935 (MKI50_001968) | 1999666..2000199 | - | 534 | WP_001004326.1 | host-nuclease inhibitor Gam family protein | - |
| MKI50_RS09940 (MKI50_001969) | 2000192..2000443 | - | 252 | WP_000683290.1 | hypothetical protein | - |
| MKI50_RS09945 (MKI50_001970) | 2000453..2000713 | - | 261 | WP_000291481.1 | DUF1108 family protein | - |
| MKI50_RS09950 (MKI50_001971) | 2000718..2001020 | - | 303 | WP_000163430.1 | DUF2482 family protein | - |
| MKI50_RS09955 (MKI50_001972) | 2001113..2001274 | - | 162 | WP_000048124.1 | DUF1270 family protein | - |
| MKI50_RS09960 (MKI50_001973) | 2001267..2001482 | - | 216 | WP_000977384.1 | hypothetical protein | - |
| MKI50_RS09965 (MKI50_001974) | 2001496..2001945 | - | 450 | WP_000993183.1 | hypothetical protein | - |
| MKI50_RS09970 (MKI50_001975) | 2001985..2002209 | - | 225 | WP_000187184.1 | hypothetical protein | - |
| MKI50_RS09975 (MKI50_001976) | 2002210..2003001 | - | 792 | WP_001157019.1 | phage antirepressor KilAC domain-containing protein | - |
| MKI50_RS09980 (MKI50_001977) | 2003058..2003297 | + | 240 | WP_000438628.1 | hypothetical protein | - |
| MKI50_RS09985 (MKI50_001978) | 2003287..2003466 | - | 180 | WP_000393082.1 | hypothetical protein | - |
| MKI50_RS09990 (MKI50_001979) | 2003481..2003924 | - | 444 | WP_000435356.1 | hypothetical protein | - |
| MKI50_RS09995 (MKI50_001980) | 2003937..2004185 | - | 249 | WP_000272859.1 | helix-turn-helix transcriptional regulator | - |
| MKI50_RS10000 (MKI50_001981) | 2004349..2004672 | + | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MKI50_RS10005 (MKI50_001982) | 2004685..2005146 | + | 462 | WP_000525008.1 | hypothetical protein | Toxin |
| MKI50_RS10010 (MKI50_001983) | 2005330..2005851 | + | 522 | WP_001102444.1 | hypothetical protein | - |
| MKI50_RS10015 (MKI50_001984) | 2005844..2006314 | + | 471 | WP_000183249.1 | hypothetical protein | - |
| MKI50_RS10020 (MKI50_001985) | 2006384..2007430 | + | 1047 | WP_001145732.1 | tyrosine-type recombinase/integrase | - |
| MKI50_RS10025 (MKI50_001986) | 2007475..2008620 | + | 1146 | WP_001245449.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| MKI50_RS10030 (MKI50_001987) | 2008880..2009410 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1962978..2007430 | 44452 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18034.35 Da Isoelectric Point: 4.6899
>T236632 WP_000525008.1 NZ_CP092567:2004685-2005146 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T236632 NZ_LR699009:c1340282-1339995 [Pluralibacter gergoviae]
ATGAGCTACAGGATTAAGTTCAGGGAGGATGCCCTGAAAGAATGGAATCGACTGGATAAGGTAATCCAACAGCAATTTGC
CAAAAAACTTAAAAAGTGCAGTGAGGACCCGCATATTCCTGCGGCAAAACTTCGTGGAATGCCTAATTGCTACAAAATCA
AGCTGCGCTCTGCCGGTTTCCGGCTGGTGTATCAGGTCATTGATGATGCGCTGATCGTTGCAGTAGTCGCCGTAGGTAAA
AGAGAGCGCGAGGATGTATATGCGCGAGCAGGCGACAGAATCAGGTAA
ATGAGCTACAGGATTAAGTTCAGGGAGGATGCCCTGAAAGAATGGAATCGACTGGATAAGGTAATCCAACAGCAATTTGC
CAAAAAACTTAAAAAGTGCAGTGAGGACCCGCATATTCCTGCGGCAAAACTTCGTGGAATGCCTAATTGCTACAAAATCA
AGCTGCGCTCTGCCGGTTTCCGGCTGGTGTATCAGGTCATTGATGATGCGCTGATCGTTGCAGTAGTCGCCGTAGGTAAA
AGAGAGCGCGAGGATGTATATGCGCGAGCAGGCGACAGAATCAGGTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT236632 WP_001260487.1 NZ_CP092567:2004349-2004672 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT236632 NZ_LR699009:c1340530-1340279 [Pluralibacter gergoviae]
ATGCCAAGCATTATATTAAGTGAAACCACCGCCAGCGTCAGCGAGCTGAAAAGTAATCCGATGGCGACAGTCAGCGCAGG
CGAAGGCTTTCCCGTCGCGATTCTCAACCGCAATAAGCCGGCTTTTTACTGCATTCCCGCAGAGTTATACGAGCGCATAC
TCGATGCGCTTGACGACCAGGAACTGGTCAGGCTGGTCAATGAGCGCAAAGACCAGAAGCTGGTCGATGTGGATCTGGAT
AGCCTGCTATGA
ATGCCAAGCATTATATTAAGTGAAACCACCGCCAGCGTCAGCGAGCTGAAAAGTAATCCGATGGCGACAGTCAGCGCAGG
CGAAGGCTTTCCCGTCGCGATTCTCAACCGCAATAAGCCGGCTTTTTACTGCATTCCCGCAGAGTTATACGAGCGCATAC
TCGATGCGCTTGACGACCAGGAACTGGTCAGGCTGGTCAATGAGCGCAAAGACCAGAAGCTGGTCGATGTGGATCTGGAT
AGCCTGCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|