Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1705393..1706061 Replicon chromosome
Accession NC_012468
Organism Streptococcus pneumoniae 70585

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag SP70585_RS09100 Protein ID WP_001132282.1
Coordinates 1705882..1706061 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID C1C926
Locus tag SP70585_RS09095 Protein ID WP_000961809.1
Coordinates 1705393..1705845 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SP70585_RS09070 1701283..1702026 - 744 WP_001188202.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
SP70585_RS09075 1702028..1702978 - 951 WP_000451126.1 50S ribosomal protein L11 methyltransferase -
SP70585_RS09080 1703116..1703544 - 429 WP_000418160.1 NUDIX hydrolase -
SP70585_RS09085 1703525..1704613 - 1089 WP_000719699.1 M50 family metallopeptidase -
SP70585_RS09090 1704632..1705102 - 471 WP_000257093.1 DUF3013 family protein -
SP70585_RS09095 1705393..1705845 - 453 WP_000961809.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SP70585_RS09100 1705882..1706061 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
SP70585_RS09105 1706198..1706377 - 180 WP_001048906.1 hypothetical protein -
SP70585_RS09110 1706581..1706781 - 201 WP_000818077.1 hypothetical protein -
SP70585_RS09115 1707051..1708322 + 1272 WP_001113235.1 replication-associated recombination protein A -
SP70585_RS09125 1708742..1709869 - 1128 WP_000323398.1 site-specific integrase -
SP70585_RS09130 1709870..1710052 - 183 WP_000655516.1 DUF3173 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T23663 WP_001132282.1 NC_012468:c1706061-1705882 [Streptococcus pneumoniae 70585]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T23663 NC_012468:c1706061-1705882 [Streptococcus pneumoniae 70585]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16645.43 Da        Isoelectric Point: 3.7154

>AT23663 WP_000961809.1 NC_012468:c1705845-1705393 [Streptococcus pneumoniae 70585]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQDPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT23663 NC_012468:c1705845-1705393 [Streptococcus pneumoniae 70585]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGACCCCATAAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
AlphaFold DB C1C926

References