Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1179417..1179915 Replicon chromosome
Accession NC_012468
Organism Streptococcus pneumoniae 70585

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag SP70585_RS06320 Protein ID WP_001809704.1
Coordinates 1179417..1179671 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag SP70585_RS06325 Protein ID WP_000208080.1
Coordinates 1179673..1179915 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SP70585_RS06305 1174689..1177157 - 2469 WP_001152990.1 DNA gyrase subunit A -
SP70585_RS06310 1177351..1178337 + 987 WP_000204725.1 L-lactate dehydrogenase -
SP70585_RS06315 1178597..1179370 - 774 WP_000731135.1 ion transporter -
SP70585_RS06320 1179417..1179671 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SP70585_RS06325 1179673..1179915 - 243 WP_000208080.1 hypothetical protein Antitoxin
SP70585_RS06330 1180006..1180815 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
SP70585_RS06335 1180817..1182166 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
SP70585_RS06340 1182159..1182863 - 705 WP_000722076.1 response regulator transcription factor -
SP70585_RS06345 1182918..1184093 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T23662 WP_001809704.1 NC_012468:c1179671-1179417 [Streptococcus pneumoniae 70585]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T23662 NC_012468:c1179671-1179417 [Streptococcus pneumoniae 70585]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGATCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT23662 WP_000208080.1 NC_012468:c1179915-1179673 [Streptococcus pneumoniae 70585]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT23662 NC_012468:c1179915-1179673 [Streptococcus pneumoniae 70585]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References