Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1962454..1963251 | Replicon | chromosome |
| Accession | NZ_CP092565 | ||
| Organism | Staphylococcus aureus strain MRSA-WC061 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MKI65_RS09680 | Protein ID | WP_000525008.1 |
| Coordinates | 1962790..1963251 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | MKI65_RS09675 | Protein ID | WP_001260487.1 |
| Coordinates | 1962454..1962777 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI65_RS09610 (MKI65_001907) | 1957771..1958304 | - | 534 | WP_001004326.1 | host-nuclease inhibitor Gam family protein | - |
| MKI65_RS09615 (MKI65_001908) | 1958297..1958548 | - | 252 | WP_000683290.1 | hypothetical protein | - |
| MKI65_RS09620 (MKI65_001909) | 1958558..1958818 | - | 261 | WP_000291481.1 | DUF1108 family protein | - |
| MKI65_RS09625 (MKI65_001910) | 1958823..1959125 | - | 303 | WP_000163430.1 | DUF2482 family protein | - |
| MKI65_RS09630 (MKI65_001911) | 1959218..1959379 | - | 162 | WP_000048124.1 | DUF1270 family protein | - |
| MKI65_RS09635 (MKI65_001912) | 1959372..1959587 | - | 216 | WP_000977384.1 | hypothetical protein | - |
| MKI65_RS09640 (MKI65_001913) | 1959601..1960050 | - | 450 | WP_000993183.1 | hypothetical protein | - |
| MKI65_RS09645 (MKI65_001914) | 1960090..1960314 | - | 225 | WP_000187184.1 | hypothetical protein | - |
| MKI65_RS09650 (MKI65_001915) | 1960315..1961106 | - | 792 | WP_001157019.1 | phage antirepressor KilAC domain-containing protein | - |
| MKI65_RS09655 (MKI65_001916) | 1961163..1961402 | + | 240 | WP_000438628.1 | hypothetical protein | - |
| MKI65_RS09660 (MKI65_001917) | 1961392..1961571 | - | 180 | WP_000393082.1 | hypothetical protein | - |
| MKI65_RS09665 (MKI65_001918) | 1961586..1962029 | - | 444 | WP_000435356.1 | hypothetical protein | - |
| MKI65_RS09670 (MKI65_001919) | 1962042..1962266 | - | 225 | WP_224732853.1 | helix-turn-helix transcriptional regulator | - |
| MKI65_RS09675 (MKI65_001920) | 1962454..1962777 | + | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MKI65_RS09680 (MKI65_001921) | 1962790..1963251 | + | 462 | WP_000525008.1 | hypothetical protein | Toxin |
| MKI65_RS09685 (MKI65_001922) | 1963435..1963956 | + | 522 | WP_001102444.1 | hypothetical protein | - |
| MKI65_RS09690 (MKI65_001923) | 1963949..1964419 | + | 471 | WP_000183249.1 | hypothetical protein | - |
| MKI65_RS09695 (MKI65_001924) | 1964489..1965535 | + | 1047 | WP_001145732.1 | tyrosine-type recombinase/integrase | - |
| MKI65_RS09700 (MKI65_001925) | 1965580..1966725 | + | 1146 | WP_001245449.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| MKI65_RS09705 (MKI65_001926) | 1966985..1967515 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1921082..1965535 | 44453 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18034.35 Da Isoelectric Point: 4.6899
>T236618 WP_000525008.1 NZ_CP092565:1962790-1963251 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T236618 NZ_LR699007:c906153-905950 [Morganella morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAAAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAAAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT236618 WP_001260487.1 NZ_CP092565:1962454-1962777 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT236618 NZ_LR699007:c906576-906217 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTTGTCCACTAA
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGGCCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAGCATGCTGACCAGCGAGGGGCATCTTGTCCACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|