236613

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2499325..2499848 Replicon chromosome
Accession NZ_CP092563
Organism Staphylococcus aureus strain MRSA-WC090

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag MKI59_RS12475 Protein ID WP_000074049.1
Coordinates 2499325..2499591 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag MKI59_RS12480 Protein ID WP_000587616.1
Coordinates 2499591..2499848 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKI59_RS12455 (MKI59_002473) 2494632..2495819 - 1188 WP_000026189.1 MFS transporter -
MKI59_RS12460 (MKI59_002474) 2496215..2496991 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
MKI59_RS12465 (MKI59_002475) 2496984..2497646 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
MKI59_RS12470 (MKI59_002476) 2497894..2498970 - 1077 WP_001076673.1 M42 family metallopeptidase -
MKI59_RS12475 (MKI59_002477) 2499325..2499591 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
MKI59_RS12480 (MKI59_002478) 2499591..2499848 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKI59_RS12485 (MKI59_002479) 2500207..2500662 + 456 WP_000732076.1 DUF1307 domain-containing protein -
MKI59_RS12490 (MKI59_002480) 2500830..2502395 - 1566 WP_000143492.1 FMN-binding glutamate synthase family protein -
MKI59_RS12495 (MKI59_002481) 2502590..2503339 + 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T236613 WP_000074049.1 NZ_CP092563:c2499591-2499325 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T236613 NZ_LR699006:3329697-3329800 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT236613 WP_000587616.1 NZ_CP092563:c2499848-2499591 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT236613 NZ_LR699006:c3329805-3329662 [Citrobacter freundii]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References