Detailed information of TA system TA236603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 852280..852757
• Replicon: chromosome
• Accession: NZ_CP092563
• Organism: Staphylococcus aureus strain MRSA-WC090

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MKI59_RS04090
• Protein ID: WP_000052076.1
• Coordinates: 852280..852468 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MKI59_RS04095
• Protein ID: WP_001059690.1
• Coordinates: 852497..852757 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKI59_RS04060 (MKI59_000802)	848274..848795	+	522	WP_000824482.1	hypothetical protein	-
MKI59_RS04065 (MKI59_000803)	849136..849822	+	687	WP_000141557.1	thermonuclease family protein	-
MKI59_RS04070 (MKI59_000804)	850179..850379	+	201	WP_001059082.1	cold-shock protein	-
MKI59_RS04075 (MKI59_000805)	850871..851089	-	219	WP_000005886.1	hypothetical protein	-
MKI59_RS04080 (MKI59_000806)	851151..851435	-	285	WP_001004399.1	hypothetical protein	-
MKI59_RS04085 (MKI59_000807)	851523..852092	-	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
MKI59_RS04090 (MKI59_000808)	852280..852468	-	189	WP_000052076.1	hypothetical protein	Toxin
MKI59_RS04095 (MKI59_000809)	852497..852757	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MKI59_RS04100 (MKI59_000810)	853098..853301	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MKI59_RS04105 (MKI59_000811)	853298..853534	-	237	WP_000349581.1	hypothetical protein	-
MKI59_RS04110 (MKI59_000812)	853759..854340	+	582	WP_001140693.1	histidine phosphatase family protein	-
MKI59_RS04115 (MKI59_000813)	854413..855030	-	618	WP_000255551.1	LysE/ArgO family amino acid transporter	-
MKI59_RS04120 (MKI59_000814)	855185..855679	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MKI59_RS04125 (MKI59_000815)	856078..856500	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
MKI59_RS04130 (MKI59_000816)	856648..857364	+	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	818602..863356	44754

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-103)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-56)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T236603 WP_000052076.1 NZ_CP092563:c852468-852280 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T236603 NZ_LR699003:c1073761-1073438 [Bifidobacterium breve]
ATGAAACGAGGTGAGATTTGGACGTTGCAGGCCGATGGCTACGCCAGCAAGCCACGGCCGGTTGTCATCGTGCAGAGCGA
TGCCGTCGATCGGTTCGATTCCGTCATCACTTGTCTGCTGACCTCATACGATTCCTCCGACATCGACACGCGGGTCCGAT
TGGAACCAAGTCCGGAGAACGGCCTGAACAAAGTGAGTTACGTGATGACGGACAAGATCGTCACCGTCGACCGCAAACTG
CTGGGATACCAAGTCGGCGTGGTTGATGATGCAGCCATGGCGAATATCGGCCGTCAGCTCATGCGGGTTCTAGGTTTGCT
GTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT236603 WP_001059690.1 NZ_CP092563:c852757-852497 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT236603 NZ_LR699003:c1073993-1073748 [Bifidobacterium breve]
ATGAGCATGCAGATTGCCACGCGAGTTGATGACGAGCAGGCTGCGTTGTTTAAGGAGACGACCCGACAGCTGGGTACCAC
CCCGGCCGATGCCCTGCGTATGTTCATCAGCGCGTTCAATGATTACCGTGGGTTCCCCTATGAGGTGCGTTTGCCACGAA
ATGACGTGGAGCCGTTTGCGTCCGAGCGGGACGCTACTGAGTATGCCAGTCGTCTCGCCTTGAGGATGTCCGATGAAACG
AGGTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56