Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1961947..1962744 | Replicon | chromosome |
| Accession | NZ_CP092561 | ||
| Organism | Staphylococcus aureus strain MRSA-WC101 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MKI54_RS09680 | Protein ID | WP_000525008.1 |
| Coordinates | 1962283..1962744 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | MKI54_RS09675 | Protein ID | WP_001260487.1 |
| Coordinates | 1961947..1962270 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKI54_RS09610 (MKI54_001906) | 1957264..1957797 | - | 534 | WP_001004326.1 | host-nuclease inhibitor Gam family protein | - |
| MKI54_RS09615 (MKI54_001907) | 1957790..1958041 | - | 252 | WP_000683290.1 | hypothetical protein | - |
| MKI54_RS09620 (MKI54_001908) | 1958051..1958311 | - | 261 | WP_000291481.1 | DUF1108 family protein | - |
| MKI54_RS09625 (MKI54_001909) | 1958316..1958618 | - | 303 | WP_000163430.1 | DUF2482 family protein | - |
| MKI54_RS09630 (MKI54_001910) | 1958711..1958872 | - | 162 | WP_000048124.1 | DUF1270 family protein | - |
| MKI54_RS09635 (MKI54_001911) | 1958865..1959080 | - | 216 | WP_000977384.1 | hypothetical protein | - |
| MKI54_RS09640 (MKI54_001912) | 1959094..1959543 | - | 450 | WP_000993183.1 | hypothetical protein | - |
| MKI54_RS09645 (MKI54_001913) | 1959583..1959807 | - | 225 | WP_000187184.1 | hypothetical protein | - |
| MKI54_RS09650 (MKI54_001914) | 1959808..1960599 | - | 792 | WP_001157019.1 | phage antirepressor KilAC domain-containing protein | - |
| MKI54_RS09655 (MKI54_001915) | 1960656..1960895 | + | 240 | WP_000438628.1 | hypothetical protein | - |
| MKI54_RS09660 (MKI54_001916) | 1960885..1961064 | - | 180 | WP_000393082.1 | hypothetical protein | - |
| MKI54_RS09665 (MKI54_001917) | 1961079..1961522 | - | 444 | WP_000435356.1 | hypothetical protein | - |
| MKI54_RS09670 (MKI54_001918) | 1961535..1961783 | - | 249 | WP_000272859.1 | helix-turn-helix transcriptional regulator | - |
| MKI54_RS09675 (MKI54_001919) | 1961947..1962270 | + | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MKI54_RS09680 (MKI54_001920) | 1962283..1962744 | + | 462 | WP_000525008.1 | hypothetical protein | Toxin |
| MKI54_RS09685 (MKI54_001921) | 1962928..1963449 | + | 522 | WP_001102444.1 | hypothetical protein | - |
| MKI54_RS09690 (MKI54_001922) | 1963442..1963912 | + | 471 | WP_000183249.1 | hypothetical protein | - |
| MKI54_RS09695 (MKI54_001923) | 1963982..1965028 | + | 1047 | WP_001145732.1 | tyrosine-type recombinase/integrase | - |
| MKI54_RS09700 (MKI54_001924) | 1965073..1966218 | + | 1146 | WP_001245449.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| MKI54_RS09705 (MKI54_001925) | 1966478..1967008 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1920575..1965028 | 44453 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18034.35 Da Isoelectric Point: 4.6899
>T236596 WP_000525008.1 NZ_CP092561:1962283-1962744 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T236596 NZ_LR698987:c3158764-3158495 [Leminorella richardii]
ATGTGGGTTGAATGGACTGATGACGCTCAGGAAGAGCTATGGGCAATTATCGATTACATTGACGATTACAATTCTCAAGC
GGCCTTTCAACTTTACAGAGATATTATTGCTGCTACAGAAGCTCTACTTTCTTACCCTTATAGACATCGCCAAGGAAGAG
TATTAAGCACGCGGGAAATTGTAGTTCATCCTAACTATATTGTTGTTTATCGAATTTCTGACCGCATTGAAATTCTTAGT
GTTCTACATGCAAAGCGGGAGTATCCCTGA
ATGTGGGTTGAATGGACTGATGACGCTCAGGAAGAGCTATGGGCAATTATCGATTACATTGACGATTACAATTCTCAAGC
GGCCTTTCAACTTTACAGAGATATTATTGCTGCTACAGAAGCTCTACTTTCTTACCCTTATAGACATCGCCAAGGAAGAG
TATTAAGCACGCGGGAAATTGTAGTTCATCCTAACTATATTGTTGTTTATCGAATTTCTGACCGCATTGAAATTCTTAGT
GTTCTACATGCAAAGCGGGAGTATCCCTGA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT236596 WP_001260487.1 NZ_CP092561:1961947-1962270 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT236596 NZ_LR698987:c3158945-3158754 [Leminorella richardii]
ATGACGATAAAGCCATCGCCTACCGAATCCGAGTTTGAGACTCAGGAACAGGCCAATAGTTACGATCGCTGGTTTAGGGC
TAAGGTTGAAGCCGCAATGAACAGCGCTAAGCCTCGGATCCCGCATGAGCAAGTTATTGCTGAAATACAGGTGCGTTTGG
ACGCAAAGCGAAAGGTACATAATGTGGGTTGA
ATGACGATAAAGCCATCGCCTACCGAATCCGAGTTTGAGACTCAGGAACAGGCCAATAGTTACGATCGCTGGTTTAGGGC
TAAGGTTGAAGCCGCAATGAACAGCGCTAAGCCTCGGATCCCGCATGAGCAAGTTATTGCTGAAATACAGGTGCGTTTGG
ACGCAAAGCGAAAGGTACATAATGTGGGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|